4nn1: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older edit
No edit summary
No edit summary
 
(5 intermediate revisions by the same user not shown)
Line 1: Line 1:
{{STRUCTURE_4nn1|  PDB=4nn1  |  SCENE=  }}
===Crystal Structure of transcriptional regulator Rv1219c of Mycobacterium tuberculosis===
{{ABSTRACT_PUBMED_22821564}}


==About this Structure==
==Crystal Structure of transcriptional regulator Rv1219c of Mycobacterium tuberculosis==
[[4nn1]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NN1 OCA].  
<StructureSection load='4nn1' size='340' side='right'caption='[[4nn1]], [[Resolution|resolution]] 2.99&Aring;' scene=''>
 
== Structural highlights ==
==Reference==
<table><tr><td colspan='2'>[[4nn1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NN1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NN1 FirstGlance]. <br>
<ref group="xtra">PMID:022821564</ref><references group="xtra"/><references/>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.99&#8491;</td></tr>
[[Category: Chou, T H.]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nn1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nn1 OCA], [https://pdbe.org/4nn1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nn1 RCSB], [https://www.ebi.ac.uk/pdbsum/4nn1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nn1 ProSAT]</span></td></tr>
[[Category: Kumar, N.]]
</table>
[[Category: Radhakrishnan, A.]]
== Function ==
[[Category: Yu, E.]]
[https://www.uniprot.org/uniprot/RAAS_MYCTU RAAS_MYCTU] Regulates the expression of the Rv1217c-Rv1218c multidrug efflux system and its own expression. Acts by binding to promoter regions of Rv1219c and upstream of the Rv1218c gene (PubMed:24424575). Important for survival in prolonged stationary phase and during macrophage infection (PubMed:24590482). May be used to eliminate non-growing mycobacteria (PubMed:25012658).<ref>PMID:24424575</ref> <ref>PMID:24590482</ref> <ref>PMID:25012658</ref>
[[Category: Dna binding]]
== References ==
[[Category: Dna binding transcriptional regulator]]
<references/>
[[Category: Helix turn helix motif]]
__TOC__
[[Category: Transcription]]
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Chou T-H]]
[[Category: Kumar N]]
[[Category: Radhakrishnan A]]
[[Category: Yu E]]

Latest revision as of 15:34, 1 March 2024

Crystal Structure of transcriptional regulator Rv1219c of Mycobacterium tuberculosisCrystal Structure of transcriptional regulator Rv1219c of Mycobacterium tuberculosis

Structural highlights

4nn1 is a 1 chain structure with sequence from Mycobacterium tuberculosis H37Rv. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.99Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RAAS_MYCTU Regulates the expression of the Rv1217c-Rv1218c multidrug efflux system and its own expression. Acts by binding to promoter regions of Rv1219c and upstream of the Rv1218c gene (PubMed:24424575). Important for survival in prolonged stationary phase and during macrophage infection (PubMed:24590482). May be used to eliminate non-growing mycobacteria (PubMed:25012658).[1] [2] [3]

References

  1. ↑ Kumar N, Radhakrishnan A, Wright CC, Chou TH, Lei HT, Bolla JR, Tringides ML, Rajashankar KR, Su CC, Purdy GE, Yu EW. Crystal Structure of the transcriptional regulator Rv1219c of Mycobacterium tuberculosis. Protein Sci. 2014 Jan 14. doi: 10.1002/pro.2424. PMID:24424575 doi:http://dx.doi.org/10.1002/pro.2424
  2. ↑ Turapov O, Waddell SJ, Burke B, Glenn S, Sarybaeva AA, Tudo G, Labesse G, Young DI, Young M, Andrew PW, Butcher PD, Cohen-Gonsaud M, Mukamolova GV. Antimicrobial treatment improves mycobacterial survival in nonpermissive growth conditions. Antimicrob Agents Chemother. 2014 May;58(5):2798-806. doi: 10.1128/AAC.02774-13. , Epub 2014 Mar 3. PMID:24590482 doi:http://dx.doi.org/10.1128/AAC.02774-13
  3. ↑ Turapov O, Waddell SJ, Burke B, Glenn S, Sarybaeva AA, Tudo G, Labesse G, Young DI, Young M, Andrew PW, Butcher PD, Cohen-Gonsaud M, Mukamolova GV. Oleoyl coenzyme A regulates interaction of transcriptional regulator RaaS (Rv1219c) with DNA in mycobacteria. J Biol Chem. 2014 Sep 5;289(36):25241-9. doi: 10.1074/jbc.M114.577338. Epub 2014 , Jul 10. PMID:25012658 doi:http://dx.doi.org/10.1074/jbc.M114.577338

4nn1, resolution 2.99Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=4nn1&oldid=4075605"