4nn1

Crystal Structure of transcriptional regulator Rv1219c of Mycobacterium tuberculosisCrystal Structure of transcriptional regulator Rv1219c of Mycobacterium tuberculosis

Structural highlights

4nn1 is a 1 chain structure with sequence from Mycobacterium tuberculosis H37Rv. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.99Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RAAS_MYCTU Regulates the expression of the Rv1217c-Rv1218c multidrug efflux system and its own expression. Acts by binding to promoter regions of Rv1219c and upstream of the Rv1218c gene (PubMed:24424575). Important for survival in prolonged stationary phase and during macrophage infection (PubMed:24590482). May be used to eliminate non-growing mycobacteria (PubMed:25012658).^[1] ^[2] ^[3]

References

↑ Kumar N, Radhakrishnan A, Wright CC, Chou TH, Lei HT, Bolla JR, Tringides ML, Rajashankar KR, Su CC, Purdy GE, Yu EW. Crystal Structure of the transcriptional regulator Rv1219c of Mycobacterium tuberculosis. Protein Sci. 2014 Jan 14. doi: 10.1002/pro.2424. PMID:24424575 doi:http://dx.doi.org/10.1002/pro.2424
↑ Turapov O, Waddell SJ, Burke B, Glenn S, Sarybaeva AA, Tudo G, Labesse G, Young DI, Young M, Andrew PW, Butcher PD, Cohen-Gonsaud M, Mukamolova GV. Antimicrobial treatment improves mycobacterial survival in nonpermissive growth conditions. Antimicrob Agents Chemother. 2014 May;58(5):2798-806. doi: 10.1128/AAC.02774-13. , Epub 2014 Mar 3. PMID:24590482 doi:http://dx.doi.org/10.1128/AAC.02774-13
↑ Turapov O, Waddell SJ, Burke B, Glenn S, Sarybaeva AA, Tudo G, Labesse G, Young DI, Young M, Andrew PW, Butcher PD, Cohen-Gonsaud M, Mukamolova GV. Oleoyl coenzyme A regulates interaction of transcriptional regulator RaaS (Rv1219c) with DNA in mycobacteria. J Biol Chem. 2014 Sep 5;289(36):25241-9. doi: 10.1074/jbc.M114.577338. Epub 2014 , Jul 10. PMID:25012658 doi:http://dx.doi.org/10.1074/jbc.M114.577338

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OCA

[1] Kumar N, Radhakrishnan A, Wright CC, Chou TH, Lei HT, Bolla JR, Tringides ML, Rajashankar KR, Su CC, Purdy GE, Yu EW. Crystal Structure of the transcriptional regulator Rv1219c of Mycobacterium tuberculosis. Protein Sci. 2014 Jan 14. doi: 10.1002/pro.2424. PMID:24424575 doi:http://dx.doi.org/10.1002/pro.2424

[2] Turapov O, Waddell SJ, Burke B, Glenn S, Sarybaeva AA, Tudo G, Labesse G, Young DI, Young M, Andrew PW, Butcher PD, Cohen-Gonsaud M, Mukamolova GV. Antimicrobial treatment improves mycobacterial survival in nonpermissive growth conditions. Antimicrob Agents Chemother. 2014 May;58(5):2798-806. doi: 10.1128/AAC.02774-13. , Epub 2014 Mar 3. PMID:24590482 doi:http://dx.doi.org/10.1128/AAC.02774-13

[3] Turapov O, Waddell SJ, Burke B, Glenn S, Sarybaeva AA, Tudo G, Labesse G, Young DI, Young M, Andrew PW, Butcher PD, Cohen-Gonsaud M, Mukamolova GV. Oleoyl coenzyme A regulates interaction of transcriptional regulator RaaS (Rv1219c) with DNA in mycobacteria. J Biol Chem. 2014 Sep 5;289(36):25241-9. doi: 10.1074/jbc.M114.577338. Epub 2014 , Jul 10. PMID:25012658 doi:http://dx.doi.org/10.1074/jbc.M114.577338

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