Cytidine monophosphate kinase: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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-<StructureSection load='2cmk' size='350' side='right' caption='Structure of E. coli cytidine monophosphate kinase complex with CDP (stick model) and sulfate (PDB entry [[2cmk]])' scene=''>
+<StructureSection load='' size='350' side='right' caption='Structure of E. coli cytidine monophosphate kinase complex with CMP (PDB entry [[1kdo]])' scene='57/573961/Cv/1'>
-'''Cytidine monophosphate kinase''' (CMK) catalyzes the reversible conversion of CMP and ATP to CDP and ADP.
+'''Cytidine monophosphate kinase''' or '''cytidylate kinase''' (CMK) catalyzes the reversible conversion of CMP and ATP to CDP and ADP.  <ref>PMID:9862805</ref>
+== Relevance ==
+CMK from bacterial pathogens is a target for new antibiotics development.
+== Structural highlights ==
+<scene name='57/573961/Cv/4'>CMK active site</scene> is highly sugar-specific.<ref>PMID:11827479</ref> Water molecules are shown as red spheres.
+</StructureSection>
 ==3D structures of cytidine monophosphate kinase==
-[[1cke]] – EcCMK – ''Escherichia coli''<br />
+(Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}})
-[[2fem]] – EcCMK (mutant)<br />
-[[1q3t]] – CMK – ''Streptococcus pneumoniae''<br />
+{{#tree:id=OrganizedByTopic|openlevels=0|
-[[3r8c]] – MaCMK – ''Mycobacterium abscessus''<br />
-[[3r20]] – CMK – ''Mycobacterium smegmatis''<br />
+*CMK
-[[4e22]] – CMK – ''Yersinia pseudotuberculosis''<br />
-[[3w90]] – TtCMK – ''Thermus thermophilus''<br />
+**[[1tev]] – CMK – human<br />
+**[[1cke]] – EcCMK – ''Escherichia coli''<br />
+**[[2fem]] – EcCMK (mutant)<br />
+**[[1q3t]] – CMK – ''Streptococcus pneumoniae''<br />
+**[[3r8c]] – MaCMK – ''Mycobacterium abscessus''<br />
+**[[3r20]] – CMK – ''Mycobacterium smegmatis''<br />
+**[[4e22]] – CMK – ''Yersinia pseudotuberculosis''<br />
+**[[3w90]] – TtCMK – ''Thermus thermophilus''<br />
-===CMK complex with ligand===
+*CMK complex with ligand
-[[2cmk]] – EcCMK + CDP<br />
+**[[2cmk]] – EcCMK + CDP<br />
-[[3akd]] – TtCMK + CDP <br />
+**[[3akd]] – TtCMK + CDP <br />
-[[3ake]], [[3w8n]] – TtCMK + CMP<br />
+**[[7ckj]], [[3w8n]] – TtCMK + CMP<br />
-[[4die]] – MaCMK + CMP<br />
+**[[4die]] – MaCMK + CMP<br />
-[[1kdo]] – EcCMK + CMP<br />
+**[[1kdo]] – EcCMK + CMP<br />
-[[1kdp]] – EcCMK + dCMP<br />
+**[[1kdp]] – EcCMK + dCMP<br />
-[[2feo]] – EcCMK (mutant) + dCMP<br />
+**[[2feo]] – EcCMK (mutant) + dCMP<br />
-[[1kdr]] – EcCMK + ara-CMP<br />
+**[[1kdr]] – EcCMK + ara-CMP<br />
-[[1kdt]] – EcCMK + ddCMP<br />
+**[[1kdt]] – EcCMK + ddCMP<br />
-[[2h92]] – CMK + CMP – ''Staphylococcus aureus''<br />
+**[[2h92]] – CMK + CMP – ''Staphylococcus aureus''<br />
-[[3akc]] – TtCMK + CDP + ADP <br />
+**[[7ckj]] – TtCMK + CMP <br />
+**[[3akc]] – TtCMK + CDP + ADP <br />
+**[[7l4a]] – CMK + CDP – ''Encephalitozoon cuniculi''<br />
+}}
+== References ==
+<references/>
+[[Category: Topic Page]]