Cytidine monophosphate kinase

Cytidine monophosphate kinase or cytidylate kinase (CMK) catalyzes the reversible conversion of CMP and ATP to CDP and ADP. Relevance CMK from bacterial pathogens is a target for new antibiotics development. Structural highlights is highly sugar-specific. Water molecules are shown as red spheres.

spinqualitylabelsall models Structure of E. coli cytidine monophosphate kinase complex with CMP (PDB entry 1kdo) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of cytidine monophosphate kinase3D structures of cytidine monophosphate kinase

(Updated on 16-June-2021)

{"openlevels":0}

• CMK
  • 1tev – CMK – human
    
  • 1cke – EcCMK – Escherichia coli
    
  • 2fem – EcCMK (mutant)
    
  • 1q3t – CMK – Streptococcus pneumoniae
    
  • 3r8c – MaCMK – Mycobacterium abscessus
    
  • 3r20 – CMK – Mycobacterium smegmatis
    
  • 4e22 – CMK – Yersinia pseudotuberculosis
    
  • 3w90 – TtCMK – Thermus thermophilus
    
• CMK complex with ligand
  • 2cmk – EcCMK + CDP
    
  • 3akd – TtCMK + CDP
    
  • 7ckj, 3w8n – TtCMK + CMP
    
  • 4die – MaCMK + CMP
    
  • 1kdo – EcCMK + CMP
    
  • 1kdp – EcCMK + dCMP
    
  • 2feo – EcCMK (mutant) + dCMP
    
  • 1kdr – EcCMK + ara-CMP
    
  • 1kdt – EcCMK + ddCMP
    
  • 2h92 – CMK + CMP – Staphylococcus aureus
    
  • 7ckj – TtCMK + CMP
    
  • 3akc – TtCMK + CDP + ADP
    
  • 7l4a – CMK + CDP – Encephalitozoon cuniculi