Cytidine monophosphate kinase: Difference between revisions
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Michal Harel (talk | contribs) New page: <StructureSection load='2cmk' size='350' side='right' caption='Structure of E. coli cytidine monophosphate kinase complex with CDP (PDB entry 2cmk)' scene=''> '''Cytidine monopho... |
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<StructureSection load='' size='350' side='right' caption='Structure of E. coli cytidine monophosphate kinase complex with CMP (PDB entry [[1kdo]])' scene='57/573961/Cv/1'> | |||
'''Cytidine monophosphate kinase''' or '''cytidylate kinase''' (CMK) catalyzes the reversible conversion of CMP and ATP to CDP and ADP. <ref>PMID:9862805</ref> | |||
== Relevance == | |||
CMK from bacterial pathogens is a target for new antibiotics development. | |||
== Structural highlights == | |||
<scene name='57/573961/Cv/4'>CMK active site</scene> is highly sugar-specific.<ref>PMID:11827479</ref> Water molecules are shown as red spheres. | |||
</StructureSection> | |||
==3D structures of cytidine monophosphate kinase== | ==3D structures of cytidine monophosphate kinase== | ||
[[1cke]] – EcCMK – ''Escherichia coli''<br /> | (Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}) | ||
[[2fem]] – EcCMK (mutant)<br /> | |||
[[1q3t]] – CMK – ''Streptococcus pneumoniae''<br /> | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
[[3r8c]] – MaCMK – ''Mycobacterium abscessus''<br /> | |||
[[3r20]] – CMK – ''Mycobacterium smegmatis''<br /> | *CMK | ||
[[4e22]] – CMK – ''Yersinia pseudotuberculosis''<br /> | |||
[[3w90]] – TtCMK – ''Thermus thermophilus''<br /> | **[[1tev]] – CMK – human<br /> | ||
**[[1cke]] – EcCMK – ''Escherichia coli''<br /> | |||
**[[2fem]] – EcCMK (mutant)<br /> | |||
**[[1q3t]] – CMK – ''Streptococcus pneumoniae''<br /> | |||
**[[3r8c]] – MaCMK – ''Mycobacterium abscessus''<br /> | |||
**[[3r20]] – CMK – ''Mycobacterium smegmatis''<br /> | |||
**[[4e22]] – CMK – ''Yersinia pseudotuberculosis''<br /> | |||
**[[3w90]] – TtCMK – ''Thermus thermophilus''<br /> | |||
*CMK complex with ligand | |||
[[2cmk]] – EcCMK + CDP<br /> | **[[2cmk]] – EcCMK + CDP<br /> | ||
[[3akd]] – TtCMK + CDP <br /> | **[[3akd]] – TtCMK + CDP <br /> | ||
[[ | **[[7ckj]], [[3w8n]] – TtCMK + CMP<br /> | ||
[[4die]] – MaCMK + CMP<br /> | **[[4die]] – MaCMK + CMP<br /> | ||
[[1kdo]] – EcCMK + CMP<br /> | **[[1kdo]] – EcCMK + CMP<br /> | ||
[[1kdp]] – EcCMK + dCMP<br /> | **[[1kdp]] – EcCMK + dCMP<br /> | ||
[[2feo]] – EcCMK (mutant) + dCMP<br /> | **[[2feo]] – EcCMK (mutant) + dCMP<br /> | ||
[[1kdr]] – EcCMK + ara-CMP<br /> | **[[1kdr]] – EcCMK + ara-CMP<br /> | ||
[[1kdt]] – EcCMK + ddCMP<br /> | **[[1kdt]] – EcCMK + ddCMP<br /> | ||
[[2h92]] – CMK + CMP – ''Staphylococcus aureus''<br /> | **[[2h92]] – CMK + CMP – ''Staphylococcus aureus''<br /> | ||
[[3akc]] – TtCMK + CDP + ADP <br /> | **[[7ckj]] – TtCMK + CMP <br /> | ||
**[[3akc]] – TtCMK + CDP + ADP <br /> | |||
**[[7l4a]] – CMK + CDP – ''Encephalitozoon cuniculi''<br /> | |||
}} | |||
== References == | |||
<references/> | |||
[[Category: Topic Page]] | |||