3qph: Difference between revisions

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{{STRUCTURE_3qph|  PDB=3qph  |  SCENE=  }}
===The three-dimensional structure of TrmB, a global transcriptional regulator of the hyperthermophilic archaeon Pyrococcus furiosus in complex with sucrose===
{{ABSTRACT_PUBMED_23576322}}


==About this Structure==
==The three-dimensional structure of TrmB, a global transcriptional regulator of the hyperthermophilic archaeon Pyrococcus furiosus in complex with sucrose==
[[3qph]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QPH OCA].  
<StructureSection load='3qph' size='340' side='right'caption='[[3qph]], [[Resolution|resolution]] 2.99&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3qph]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QPH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QPH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.992&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=FRU:FRUCTOSE'>FRU</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PRD_900003:sucrose'>PRD_900003</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qph OCA], [https://pdbe.org/3qph PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qph RCSB], [https://www.ebi.ac.uk/pdbsum/3qph PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qph ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TRMBR_PYRFU TRMBR_PYRFU] Inhibits transcription of the trehalose/maltose transport gene cluster (malE operon) and of the maltodextrin transport gene cluster (mdxE operon). Acts by binding to two different operator sequences in both promoters, preventing polymerase recruitment and transcription.<ref>PMID:12426307</ref> <ref>PMID:16135241</ref>


==Reference==
==See Also==
<ref group="xtra">PMID:023576322</ref><references group="xtra"/><references/>
*[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Pyrococcus furiosus]]
[[Category: Pyrococcus furiosus]]
[[Category: Boos, W.]]
[[Category: Boos W]]
[[Category: Diederichs, K.]]
[[Category: Diederichs K]]
[[Category: Krug, M.]]
[[Category: Krug M]]
[[Category: Lee, S J.]]
[[Category: Lee S-J]]
[[Category: Welte, W.]]
[[Category: Welte W]]
[[Category: Transcription]]
[[Category: Transcriptional regulator]]

Latest revision as of 13:48, 21 February 2024

The three-dimensional structure of TrmB, a global transcriptional regulator of the hyperthermophilic archaeon Pyrococcus furiosus in complex with sucroseThe three-dimensional structure of TrmB, a global transcriptional regulator of the hyperthermophilic archaeon Pyrococcus furiosus in complex with sucrose

Structural highlights

3qph is a 1 chain structure with sequence from Pyrococcus furiosus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.992Å
Ligands:, , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TRMBR_PYRFU Inhibits transcription of the trehalose/maltose transport gene cluster (malE operon) and of the maltodextrin transport gene cluster (mdxE operon). Acts by binding to two different operator sequences in both promoters, preventing polymerase recruitment and transcription.[1] [2]

See Also

References

  1. ↑ Lee SJ, Engelmann A, Horlacher R, Qu Q, Vierke G, Hebbeln C, Thomm M, Boos W. TrmB, a sugar-specific transcriptional regulator of the trehalose/maltose ABC transporter from the hyperthermophilic archaeon Thermococcus litoralis. J Biol Chem. 2003 Jan 10;278(2):983-90. PMID:12426307 doi:10.1074/jbc.M210236200
  2. ↑ Lee SJ, Moulakakis C, Koning SM, Hausner W, Thomm M, Boos W. TrmB, a sugar sensing regulator of ABC transporter genes in Pyrococcus furiosus exhibits dual promoter specificity and is controlled by different inducers. Mol Microbiol. 2005 Sep;57(6):1797-807. PMID:16135241 doi:10.1111/j.1365-2958.2005.04804.x

3qph, resolution 2.99Å

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