2m80: Difference between revisions

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New page: '''Unreleased structure''' The entry 2m80 is ON HOLD Authors: Tang, Y., Zhang, J., Zhou, C., Shi, Y. Description: Solution structure of yeast dithiol glutaredoxin Grx8
 
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'''Unreleased structure'''


The entry 2m80 is ON HOLD
==Solution structure of yeast dithiol glutaredoxin Grx8==
 
<StructureSection load='2m80' size='340' side='right'caption='[[2m80]]' scene=''>
Authors: Tang, Y., Zhang, J., Zhou, C., Shi, Y.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2m80]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M80 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M80 FirstGlance]. <br>
Description: Solution structure of yeast dithiol glutaredoxin Grx8
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m80 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m80 OCA], [https://pdbe.org/2m80 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m80 RCSB], [https://www.ebi.ac.uk/pdbsum/2m80 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m80 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GLRX8_YEAST GLRX8_YEAST] Glutathione-dependent oxidoreductase with lower activity compared to the other members of the glutaredoxin family. The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase.<ref>PMID:18400945</ref> <ref>PMID:19166312</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Shi Y]]
[[Category: Tang Y]]
[[Category: Wu J]]
[[Category: Yu J]]
[[Category: Zhang J]]
[[Category: Zhou CZ]]

Latest revision as of 09:59, 1 May 2024

Solution structure of yeast dithiol glutaredoxin Grx8Solution structure of yeast dithiol glutaredoxin Grx8

Structural highlights

2m80 is a 1 chain structure with sequence from Saccharomyces cerevisiae S288C. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GLRX8_YEAST Glutathione-dependent oxidoreductase with lower activity compared to the other members of the glutaredoxin family. The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase.[1] [2]

References

  1. ↑ Mesecke N, Spang A, Deponte M, Herrmann JM. A novel group of glutaredoxins in the cis-Golgi critical for oxidative stress resistance. Mol Biol Cell. 2008 Jun;19(6):2673-80. doi: 10.1091/mbc.E07-09-0896. Epub 2008, Apr 9. PMID:18400945 doi:http://dx.doi.org/10.1091/mbc.E07-09-0896
  2. ↑ Eckers E, Bien M, Stroobant V, Herrmann JM, Deponte M. Biochemical characterization of dithiol glutaredoxin 8 from Saccharomyces cerevisiae: the catalytic redox mechanism redux. Biochemistry. 2009 Feb 17;48(6):1410-23. doi: 10.1021/bi801859b. PMID:19166312 doi:http://dx.doi.org/10.1021/bi801859b
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