2m80

Solution structure of yeast dithiol glutaredoxin Grx8Solution structure of yeast dithiol glutaredoxin Grx8

Structural highlights

2m80 is a 1 chain structure with sequence from Saccharomyces cerevisiae S288C. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Solution NMR
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GLRX8_YEAST Glutathione-dependent oxidoreductase with lower activity compared to the other members of the glutaredoxin family. The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase.^[1] ^[2]

References

↑ Mesecke N, Spang A, Deponte M, Herrmann JM. A novel group of glutaredoxins in the cis-Golgi critical for oxidative stress resistance. Mol Biol Cell. 2008 Jun;19(6):2673-80. doi: 10.1091/mbc.E07-09-0896. Epub 2008, Apr 9. PMID:18400945 doi:http://dx.doi.org/10.1091/mbc.E07-09-0896
↑ Eckers E, Bien M, Stroobant V, Herrmann JM, Deponte M. Biochemical characterization of dithiol glutaredoxin 8 from Saccharomyces cerevisiae: the catalytic redox mechanism redux. Biochemistry. 2009 Feb 17;48(6):1410-23. doi: 10.1021/bi801859b. PMID:19166312 doi:http://dx.doi.org/10.1021/bi801859b

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OCA

[1] Mesecke N, Spang A, Deponte M, Herrmann JM. A novel group of glutaredoxins in the cis-Golgi critical for oxidative stress resistance. Mol Biol Cell. 2008 Jun;19(6):2673-80. doi: 10.1091/mbc.E07-09-0896. Epub 2008, Apr 9. PMID:18400945 doi:http://dx.doi.org/10.1091/mbc.E07-09-0896

[2] Eckers E, Bien M, Stroobant V, Herrmann JM, Deponte M. Biochemical characterization of dithiol glutaredoxin 8 from Saccharomyces cerevisiae: the catalytic redox mechanism redux. Biochemistry. 2009 Feb 17;48(6):1410-23. doi: 10.1021/bi801859b. PMID:19166312 doi:http://dx.doi.org/10.1021/bi801859b

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