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==Crystal structure of E. coli Threonyl-tRNA synthetase bound to a novel inhibitor== | |||
<StructureSection load='4hwp' size='340' side='right'caption='[[4hwp]], [[Resolution|resolution]] 1.81Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4hwp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HWP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HWP FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.807Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=X16:N-{[3-(4-AMINO-2-METHYLQUINAZOLIN-7-YL)PHENYL]SULFONYL}-L-THREONINAMIDE'>X16</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hwp OCA], [https://pdbe.org/4hwp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hwp RCSB], [https://www.ebi.ac.uk/pdbsum/4hwp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hwp ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/SYT_ECOLI SYT_ECOLI] ThrS is also a translational repressor protein, it controls the translation of its own gene by binding to its mRNA.[HAMAP-Rule:MF_00184] | |||
==See Also== | |||
*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Escherichia coli K-12]] | |||
[[Category: Large Structures]] | |||
[[Category: Hilgers MT]] | |||
Latest revision as of 14:46, 1 March 2024
Crystal structure of E. coli Threonyl-tRNA synthetase bound to a novel inhibitorCrystal structure of E. coli Threonyl-tRNA synthetase bound to a novel inhibitor
Structural highlights
FunctionSYT_ECOLI ThrS is also a translational repressor protein, it controls the translation of its own gene by binding to its mRNA.[HAMAP-Rule:MF_00184] See Also |
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