Trichodiene synthase: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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+<StructureSection load='' size='350' side='right' caption='Trichodiene synthase complex with diphosphate, competitive inhibitor and Mg+2 ion (green) [[2q9y]]' scene='54/542259/Cv/1' pspeed='8'>
+== Function ==
+'''Trichodiene synthase''' (TCS) catalyzes the conversion of trans,trans-farnesyl diphosphate to trichodiene and diphosphate (PP).  TCS belongs to the family of sesquiterpene syntases which cyclize the acyclic farnesyl diphosphate to a sesquiterpene.  TCS contains metal ion-binding motif<ref>PMID:7875326</ref>.
-[[Image:2q9z.png|left|200px|thumb|Crystal structure of trichodiene synthase complex with diphosphate and Mg+2 ion [[2q9z]]]]
+== Structural highlights ==
-{{STRUCTURE_2q9z|  PDB=2q9z  | SIZE=350| SCENE= |right|CAPTION=Trichodiene synthase complex with diphosphate and Mg+2 ion [[2q9z]] }}
+The <scene name='54/542259/Cv/6'>active site</scene> of TCS contains <scene name='54/542259/Cv/7'>diphosphate, the competitive inhibitor benzyl-diethylethanaminium and Mg+2 ions</scene><ref>PMID:17678871</ref>.
+</StructureSection>
-'''Trichodiene synthase''' (TCS) catalyzes the conversion of trans,trans-farnesyl diphosphate to trichodiene and diphosphate (PP).  TCS belongs to the family of sesquiterpene syntases which cyclize the acyclic farnesyl diphosphate to a Sesquiterpene.  TCS contains metalion-binding motifs.
 == 3D Structures of trichodiene synthase ==
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 [[1yyr]], [[1yys]], [[1yyt]], [[1yyu]], [[2ael]], [[2aet]] – FsTCS (mutant) + PP + Mg + azabisabolene<br />
 [[2q9y]] – FsTCS + PP + Mg + benzyl triethyl ammonium<br />
+== References ==
+<references/>
+[[Category:Topic Page]]