Ecotin: Difference between revisions
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<StructureSection load='1id5' size='400' side='right' scene='46/465444/Cv/2' caption='The dimeric E. coli ecotin (yellow) complex with thrombin heavy chain (cyan) and light chain (magenta) and Ca+2 ion (green) [[1id5]]'> | |||
'''Ecotin''' (ECO) is a serine protease inhibitor found in the periplasm of E. coli. It is a potent anti and a reversible tight-binding inhibitor of human factor Xa. | '''Ecotin''' (ECO) is a serine protease inhibitor found in the periplasm of ''E. coli''. It is a potent anti and a reversible tight-binding inhibitor of human factor Xa.<ref>PMID:14705961</ref> | ||
<scene name='46/465444/Cv/7'>The dimeric E. coli ecotin</scene> with <scene name='46/465444/Cv/8'>thrombin heavy and light chains</scene>. | |||
<scene name='46/465444/Cv/9'>Ca+2 ion coordination site</scene> in thrombin heavy chain ([[1id5]]).<ref>PMID:11513582</ref> Water molecules shown as red spheres. | |||
</StructureSection> | |||
== 3D Structures of Ecotin == | == 3D Structures of Ecotin == | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
{{#tree:id=OrganizedByTopic|openlevels=0| | |||
*Ecotin | |||
**[[1ecy]], [[1ecz]] – ECO - ''Escherichia coli''<br /> | |||
**[[1ifg]] - ECO (mutant) | |||
*Ecotin complex with protein | |||
**[[1slu]], [[1slv]], [[1slw]], [[1slx]], [[1ezs]], [[1ezu]], [[4niy]] – ECO (mutant) + anionic trypsin (mutant) <br /> | |||
**[[1azz]] – ECO + collagenase<br /> | |||
**[[1id5]] - ECO (mutant) + thrombin<br /> | |||
**[[1n8o]], [[1y6t]], [[2y6t]] - ECO + chymotrypsin<br /> | |||
**[[1p0s]] - ECO (mutant) + factor Xa<br /> | |||
**[[1xx9]] - ECO (mutant) + factor Xi<br /> | |||
**[[1xxd]], [[1xxf]] - ECO (mutant) + factor Xi (mutant) <br /> | |||
**[[1fi8]] - ECO (mutant) + granzyme B<br /> | |||
**[[4iw4]] – ECO + mannan-binding lectin serine protease<br /> | |||
**[[7cbk]] – ECO + elastase<br /> | |||
**[[7pqo]] – ECO (mutant) + MASP-1<br /> | |||
**[[7pqn]] – ECO + MASP-2<br /> | |||
}} | |||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Latest revision as of 12:53, 8 February 2023
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3D Structures of Ecotin3D Structures of Ecotin
Updated on 08-February-2023
ReferencesReferences
- ↑ Eggers CT, Murray IA, Delmar VA, Day AG, Craik CS. The periplasmic serine protease inhibitor ecotin protects bacteria against neutrophil elastase. Biochem J. 2004 Apr 1;379(Pt 1):107-18. PMID:14705961 doi:http://dx.doi.org/10.1042/BJ20031790
- ↑ Wang SX, Esmon CT, Fletterick RJ. Crystal structure of thrombin-ecotin reveals conformational changes and extended interactions. Biochemistry. 2001 Aug 28;40(34):10038-46. PMID:11513582