1yn8: Difference between revisions

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[[Image:1yn8.gif|left|200px]]<br /><applet load="1yn8" size="350" color="white" frame="true" align="right" spinBox="true"
caption="1yn8, resolution 1.70&Aring;" />
'''SH3 domain of yeast NBP2'''<br />


==About this Structure==
==SH3 domain of yeast NBP2==
1YN8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] with <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YN8 OCA].  
<StructureSection load='1yn8' size='340' side='right'caption='[[1yn8]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1yn8]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YN8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YN8 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yn8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yn8 OCA], [https://pdbe.org/1yn8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yn8 RCSB], [https://www.ebi.ac.uk/pdbsum/1yn8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yn8 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NBP2_YEAST NBP2_YEAST] Negatively regulates the high-osmolarity glycerol (HOG) pathway through its negative regulation of the HOG1 kinase activity. Mediates the binding between the PTC1 phosphatase and the PBS2 MAP/ERK kinase (MEK). With PTC1, regulates endoplasmic reticulum inheritance through the cell wall integrity (CWI) MAPK pathway by modulating the MAPK, SLT2.<ref>PMID:14573466</ref> <ref>PMID:14685261</ref> <ref>PMID:16977319</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yn/1yn8_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yn8 ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Single protein]]
[[Category: Kursula I]]
[[Category: Kursula, I.]]
[[Category: Kursula P]]
[[Category: Kursula, P.]]
[[Category: Song YH]]
[[Category: Song, Y H.]]
[[Category: Wilmanns M]]
[[Category: Wilmanns, M.]]
[[Category: CA]]
[[Category: sh3 domain]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:07:02 2008''

Latest revision as of 16:38, 13 March 2024

SH3 domain of yeast NBP2SH3 domain of yeast NBP2

Structural highlights

1yn8 is a 6 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.7Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

NBP2_YEAST Negatively regulates the high-osmolarity glycerol (HOG) pathway through its negative regulation of the HOG1 kinase activity. Mediates the binding between the PTC1 phosphatase and the PBS2 MAP/ERK kinase (MEK). With PTC1, regulates endoplasmic reticulum inheritance through the cell wall integrity (CWI) MAPK pathway by modulating the MAPK, SLT2.[1] [2] [3]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Ohkuni K, Okuda A, Kikuchi A. Yeast Nap1-binding protein Nbp2p is required for mitotic growth at high temperatures and for cell wall integrity. Genetics. 2003 Oct;165(2):517-29. PMID:14573466
  2. ↑ Mapes J, Ota IM. Nbp2 targets the Ptc1-type 2C Ser/Thr phosphatase to the HOG MAPK pathway. EMBO J. 2004 Jan 28;23(2):302-11. Epub 2003 Dec 18. PMID:14685261 doi:http://dx.doi.org/10.1038/sj.emboj.7600036
  3. ↑ Du Y, Walker L, Novick P, Ferro-Novick S. Ptc1p regulates cortical ER inheritance via Slt2p. EMBO J. 2006 Oct 4;25(19):4413-22. Epub 2006 Sep 14. PMID:16977319 doi:http://dx.doi.org/10.1038/sj.emboj.7601319

1yn8, resolution 1.70Å

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