1yn8

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SH3 domain of yeast NBP2SH3 domain of yeast NBP2

Structural highlights

1yn8 is a 6 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.7Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

NBP2_YEAST Negatively regulates the high-osmolarity glycerol (HOG) pathway through its negative regulation of the HOG1 kinase activity. Mediates the binding between the PTC1 phosphatase and the PBS2 MAP/ERK kinase (MEK). With PTC1, regulates endoplasmic reticulum inheritance through the cell wall integrity (CWI) MAPK pathway by modulating the MAPK, SLT2.[1] [2] [3]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Ohkuni K, Okuda A, Kikuchi A. Yeast Nap1-binding protein Nbp2p is required for mitotic growth at high temperatures and for cell wall integrity. Genetics. 2003 Oct;165(2):517-29. PMID:14573466
  2. ↑ Mapes J, Ota IM. Nbp2 targets the Ptc1-type 2C Ser/Thr phosphatase to the HOG MAPK pathway. EMBO J. 2004 Jan 28;23(2):302-11. Epub 2003 Dec 18. PMID:14685261 doi:http://dx.doi.org/10.1038/sj.emboj.7600036
  3. ↑ Du Y, Walker L, Novick P, Ferro-Novick S. Ptc1p regulates cortical ER inheritance via Slt2p. EMBO J. 2006 Oct 4;25(19):4413-22. Epub 2006 Sep 14. PMID:16977319 doi:http://dx.doi.org/10.1038/sj.emboj.7601319

1yn8, resolution 1.70Å

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OCA
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