1kcx: Difference between revisions

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[[Image:1kcx.png|left|200px]]


{{STRUCTURE_1kcx|  PDB=1kcx  |  SCENE=  }}
==X-ray structure of NYSGRC target T-45==
 
<StructureSection load='1kcx' size='340' side='right'caption='[[1kcx]], [[Resolution|resolution]] 2.12&Aring;' scene=''>
===X-ray structure of NYSGRC target T-45===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1kcx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KCX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KCX FirstGlance]. <br>
{{ABSTRACT_PUBMED_14685275}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.12&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kcx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kcx OCA], [https://pdbe.org/1kcx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kcx RCSB], [https://www.ebi.ac.uk/pdbsum/1kcx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kcx ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/1kcx TOPSAN]</span></td></tr>
==About this Structure==
</table>
[[1kcx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KCX OCA].  
== Function ==
 
[https://www.uniprot.org/uniprot/DPYL1_MOUSE DPYL1_MOUSE] Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration.<ref>PMID:14685275</ref>  
==Reference==
== Evolutionary Conservation ==
<ref group="xtra">PMID:014685275</ref><references group="xtra"/>
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kc/1kcx_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kcx ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Burley, S K.]]
[[Category: Burley SK]]
[[Category: Deo, R C.]]
[[Category: Deo RC]]
[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics.]]
[[Category: Schmidt EF]]
[[Category: Schmidt, E F.]]
[[Category: Strittmatter SM]]
[[Category: Strittmatter, S M.]]
[[Category: Alpha/beta barrel]]
[[Category: New york sgx research center for structural genomic]]
[[Category: Nysgxrc]]
[[Category: Protein structure initiative]]
[[Category: Psi]]
[[Category: Signaling protein]]
[[Category: Structural genomic]]

Latest revision as of 10:45, 7 February 2024

X-ray structure of NYSGRC target T-45X-ray structure of NYSGRC target T-45

Structural highlights

1kcx is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.12Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

DPYL1_MOUSE Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Deo RC, Schmidt EF, Elhabazi A, Togashi H, Burley SK, Strittmatter SM. Structural bases for CRMP function in plexin-dependent semaphorin3A signaling. EMBO J. 2004 Jan 14;23(1):9-22. Epub 2003 Dec 18. PMID:14685275 doi:http://dx.doi.org/10.1038/sj.emboj.7600021

1kcx, resolution 2.12Å

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