1kcx

X-ray structure of NYSGRC target T-45X-ray structure of NYSGRC target T-45

Structural highlights

1kcx is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.12Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

DPYL1_MOUSE Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration.^[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Deo RC, Schmidt EF, Elhabazi A, Togashi H, Burley SK, Strittmatter SM. Structural bases for CRMP function in plexin-dependent semaphorin3A signaling. EMBO J. 2004 Jan 14;23(1):9-22. Epub 2003 Dec 18. PMID:14685275 doi:http://dx.doi.org/10.1038/sj.emboj.7600021

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OCA

[1] Deo RC, Schmidt EF, Elhabazi A, Togashi H, Burley SK, Strittmatter SM. Structural bases for CRMP function in plexin-dependent semaphorin3A signaling. EMBO J. 2004 Jan 14;23(1):9-22. Epub 2003 Dec 18. PMID:14685275 doi:http://dx.doi.org/10.1038/sj.emboj.7600021

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