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{{TOC limit|limit=2}}
{{TOC limit|limit=2}}
==Guide to Proteopedia Pages Concerning Hormones and their Receptors==
==Guide to Proteopedia Pages Concerning Hormones and their Receptors==
{{Structure
|PDB=
|SIZE=380|SCENE=Human_Follicle-Stimulating_Hormone_Complexed_with_its_Receptor/1fl7to1xwdmorph/4|CAPTION= FSH binding to the leucine-rich domain of Follicle Stimulating Hormone Receptor ([[1fl7]] morphing to [[1xwd]], [[resolution]] 2.92Å)
|SITE=
|LIGAND=
|ACTIVITY=
|GENE=
|DOMAIN=
|RELATEDENTRY=
|RESOURCES=
|COORDINATES=
}}
{{#tree:id=HormoneTopic|openlevels=0|
{{#tree:id=HormoneTopic|openlevels=0|
Articles in Proteopedia concerning [[Hormone]] include:
Articles in Proteopedia concerning [[Hormone]] include:
<!--* [[Follicle-stimulating hormone]] -->
* [[Hormones and their receptors]]
* [[Steroid Hormones and their receptors]]
* [[Signal transduction]]
* [[Sex steroids]]
* [[Steroids]]
* [[Human Follicle-Stimulating Hormone Complexed with its Receptor]]
* [[Human Follicle-Stimulating Hormone Complexed with its Receptor]]
* [[Estrogen receptor]]
* [[Estrogen-related receptor]]
* [[Estrogen-related receptor]]
* [[Androgen receptor|Androgen Receptor]]
* [[Leucine-rich repeat|Leucine-rich repeat proteins]]
* [[Leucine-rich repeat|Leucine-rich repeat proteins]]
* [[Human growth hormone]]
* [[Vascular Endothelial Growth Factor]]
* [[Vascular Endothelial Growth Factor]]
* [[Vascular Endothelial Growth Factor Receptor]]
* [[Vascular Endothelial Growth Factor Receptor]]
* [[Receiver domain of sensor histidine kinase CKI1]]
* [[Receiver domain of sensor histidine kinase CKI1]]
 
* [[Beta-2 Adrenergic Receptor]]
* [[Journal:JBSD:2|Neurotensin]]
* [[Neurotensin receptor]]
* [[Glucagon]]
* [[Glucagon receptor]]
* [[Hormone sensitive lipase]]
* [[Corticosteroid-binding globulin]]
* [[Erythropoietin]]
* [[Erythropoietin receptor]]
* [[Thyroid hormone receptor]]
}}
}}
<br />
<br />
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==Additional 3D Structures of Hormones and Hormone Receptors and Related Molecules==
==Additional 3D Structures of Hormones and Hormone Receptors and Related Molecules==
===Adrenaline===
[[Image:7tm labeled.png|right|400px]]
[[Beta-2 Adrenergic Receptor]]<br />
The human β2 adrenergic receptor bound to a [[hormone]] analog and G-protein ([[3sn6]]) is featured in an image on the right, and additional structures are on the [[Adrenergic receptor|Adrenergic receptor page]]. <br />
{{Template:GPCR3sn6}}
===Angiotensinogen===
===Angiotensinogen===
[[2wxw]], [[2wxx]], [[2wxy]], [[2wxz]], [[2wy0]], [[2wy1]], [[2x0b]]  - Angiotensinogen – human, rat, mouse<br /> 
[[Serpin]]   


===Chorionic Gonadotropin===
===Chorionic Gonadotropin===
[[1hrp]] - Chorionic Gonadotropin – human<br />
[[1hcn]] - Chorionic Gonadotropin – human<br />
[[1hd4]] - Alpha-subunit of Chorionic Gonadotropin – human<br />


===Follicle-Stimulating Hormone===
[[1hrp]], [[1hcn]] - hCG – human<br />
[[1fl7]] - Follicle-Stimulating Hormone – human<br />
[[1hd4]] - α-subunit of hCG <br />
[[1xwd]] - Human Follicle Stimulating Hormone complexed with its Receptor – human<br />
[[1e9j]], [[1dz7]] - α-subunit of hCG - NMR<br />
[[1qfw]] - hCG + antibody<br />


===Glucocorticoid===
=== Estrogen receptor ===
[[3mne]], [[3mno]], [[3mnp]] - Glucocorticoid Receptor Ligand-binding Domain – human<br />
[[Estrogen receptor]]


===Growth Hormone===
===Estrogen-related Receptor===
[[3hhr]] -  Growth Hormone complexed with the extracellular portion of its receptor - human<br />
[[Estrogen-related receptor]]  
[[1hwh]] -  Growth Hormone Mutant G120R complexed with the extracellular portion of its receptor - human<br />
[[1bp3]] - Growth Hormone complexed with the prolactin receptor - human<br />
[[3mjg]], [[3mjk]]  - Platelet-derived Growth Factor/Propeptide Complex and a Platelet-Derived Growth Factor/Receptor Complex  – human<br /> 
Vascular Endothelial Growth Factor – human and others, see [[VEGF#3D_Structures_of_VEGF|Vascular Endothelial Growth Factor Structures]]<br />
Vascular Endothelial Growth Factor Receptor – human, see [[VEGFR#Additional_3D_Structures_of_VEGFR|Vascular Endothelial Growth Factor Receptor Structures]]<br />
[[2xdg]] - Extracellular Domain of Human Growth Hormone Releasing Hormone Receptor – human<br />


===Insulin===
===Androgen Receptor===
[[3ir0]] , [[1mso]]  , [[1trz]] , [[2qiu]] , [[2r34]], [[2r35]] , [[2r36]], [[3ilg]], [[2kjj]] , [[2kju]]  - Insulin – human<br />
[[Androgen receptor|Nuclear Androgen Receptor]]
[[3nw5]],  [[3nw6]],  [[3nw7]] - insulin-like growth factor 1 receptor – human<br />
[[3loh]], [[2dtg]] - insulin receptor ectodomain  – human<br />
[[Glucose-dependent Insulinotropic Polypeptide Receptor]]


===Progesterone===
===Follicle-Stimulating Hormone===
[[3hq5]],[[3g8n]], [[3g8o]], [[3hq5]] - Progesterone – human<br />
[[Follicle-stimulating hormone]]


===Thyroid-Stimulating hormone===
===PACAP/glucagon family of peptide hormones===
[[3g04]] - TSH receptor in complex with a thyroid-stimulating autoantibody – human<br />
[[3n94]] - PAC1R, receptor of pituitary adenylate cyclase activating polypeptide, is a case of a crystal structure disagreeing with the NMR structure [[2jod]] and vice versa <br />
[[2jod]] -  Pituitary adenylate cyclase-activating polypeptide (residues 6'-38') complexed to the extracellular 


===Thyroid hormone===
===Glucocorticoid===
[[2nll]] - DNA-Binding domain in complex with an inverted repeat class of thyroid response element– rat<br />
[[Glucocorticoid receptor]]
[[1xzx]]


===Thyroxine===
===Glucose-dependent Insulinotropic Polypeptide===
[[2xn3]], [[2xn5]], [[2xn6]], [[2xn7]] - Thyroxine-binding Globulin  – human<br />
[[Glucose-dependent Insulinotropic Polypeptide Receptor]]


===Farnesoid X Receptor ===
===Growth Hormone===
[[3olf]], [[3omk]], [[3omm]], [[3oof]], [[3ook]], [[3okh]], [[3oki]] - Farnesoid X Receptor  – human<br />
[[Human growth hormone]] is featured [[Human growth hormone|here]].<br />


===PACAP/glucagon family of peptide hormones===
===Insulin===
[[3n94]] - PAC1R, receptor of pituitary adenylate cyclase activating polypeptide, is a case of a crystal structure disagreeing with the NMR structure [[2jod]] and vice versa <br />
[[Insulin]]
[[2jod]] -  Pituitary adenylate cyclase-activating polypeptide (residues 6'-38') complexed to the extracellular  domain of the human splice variant hPAC1-RS determined by NMR - human<br />


===Estrogen-related receptor===
===Progesterone ===
Estrogen-related recepto – human and others, see [[Estrogen-related_receptor#3D_structures_of_estrogen-related_receptor|Estrogen-related receptor structures]]<br />


 
[[1a28]] - hProgR steroid-binding domain + progesterone<br />
ADD [[3dzu]]


==See Also==
==See Also==
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* [[Membrane proteins]]
* [[Membrane proteins]]
* [[G protein-coupled receptor|G protein-coupled receptors]]
* [[G protein-coupled receptor|G protein-coupled receptors]]
 
* [[Nobel Prizes for 3D Molecular Structure]]
* [[Highest impact structures]] of all time
* [[Hormones and their receptors]]


==External Resources==
==External Resources==

Latest revision as of 15:44, 25 April 2023

In the field of modern endocrinology, a hormone is any substance, generated either externally or internally, that operates via a receptor at the cellular level, which conveys to to the cell a message to stop, start, or modulate a cellular process.

Guide to Proteopedia Pages Concerning Hormones and their ReceptorsGuide to Proteopedia Pages Concerning Hormones and their Receptors


To view automatically seeded indices concerning Hormone, see:


Additional 3D Structures of Hormones and Hormone Receptors and Related MoleculesAdditional 3D Structures of Hormones and Hormone Receptors and Related Molecules

AdrenalineAdrenaline

Beta-2 Adrenergic Receptor
The human β2 adrenergic receptor bound to a hormone analog and G-protein (3sn6) is featured in an image on the right, and additional structures are on the Adrenergic receptor page.

 
Drag the structure with the mouse to rotate
An activated G protein-coupled receptor (human β-2 adrenergic receptor in blue ) in a complex with a heterotrimeric G protein (3 subunits:reddish to orange-brown) and hormone (gold) (3sn6), resolution 3.2Å. The boundaries of the membrane in which the GPCR sits are represented in light green.



AngiotensinogenAngiotensinogen

Serpin

Chorionic GonadotropinChorionic Gonadotropin

1hrp, 1hcn - hCG – human
1hd4 - α-subunit of hCG
1e9j, 1dz7 - α-subunit of hCG - NMR
1qfw - hCG + antibody

Estrogen receptorEstrogen receptor

Estrogen receptor

Estrogen-related ReceptorEstrogen-related Receptor

Estrogen-related receptor

Androgen ReceptorAndrogen Receptor

Nuclear Androgen Receptor

Follicle-Stimulating HormoneFollicle-Stimulating Hormone

Follicle-stimulating hormone

PACAP/glucagon family of peptide hormonesPACAP/glucagon family of peptide hormones

3n94 - PAC1R, receptor of pituitary adenylate cyclase activating polypeptide, is a case of a crystal structure disagreeing with the NMR structure 2jod and vice versa
2jod - Pituitary adenylate cyclase-activating polypeptide (residues 6'-38') complexed to the extracellular

GlucocorticoidGlucocorticoid

Glucocorticoid receptor

Glucose-dependent Insulinotropic PolypeptideGlucose-dependent Insulinotropic Polypeptide

Glucose-dependent Insulinotropic Polypeptide Receptor

Growth HormoneGrowth Hormone

Human growth hormone is featured here.

InsulinInsulin

Insulin

ProgesteroneProgesterone

1a28 - hProgR steroid-binding domain + progesterone

See AlsoSee Also

External ResourcesExternal Resources

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Wayne Decatur, Tomas Klumpler, Joel L. Sussman, Michal Harel, Alexander Berchansky
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