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==Structure of the complex of the central activation domain of Gcn4 bound to the mediator co-activator domain 1 of Gal11/med15== | |||
<StructureSection load='2lpb' size='340' side='right'caption='[[2lpb]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2lpb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2ko4 2ko4]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LPB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LPB FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lpb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lpb OCA], [https://pdbe.org/2lpb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lpb RCSB], [https://www.ebi.ac.uk/pdbsum/2lpb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lpb ProSAT]</span></td></tr> | |||
== | </table> | ||
[[2lpb]] is a 2 chain structure with sequence from [ | == Function == | ||
[https://www.uniprot.org/uniprot/MED15_YEAST MED15_YEAST] Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins. It has an important role in the negative regulation of Ty transcription.<ref>PMID:16076843</ref> <ref>PMID:16109375</ref> <ref>PMID:16263706</ref> | |||
==See Also== | ==See Also== | ||
*[[Gcn4 3D Structures|Gcn4 3D Structures]] | |||
*[[Gnc4 3D Structures|Gnc4 3D Structures]] | |||
*[[Mediator|Mediator]] | *[[Mediator|Mediator]] | ||
== References == | |||
== | <references/> | ||
< | __TOC__ | ||
[[Category: Saccharomyces cerevisiae]] | </StructureSection> | ||
[[Category: Baker | [[Category: Large Structures]] | ||
[[Category: Brzovic | [[Category: Saccharomyces cerevisiae S288C]] | ||
[[Category: Hahn | [[Category: Baker D]] | ||
[[Category: Heikaus | [[Category: Brzovic PS]] | ||
[[Category: Herbig | [[Category: Hahn S]] | ||
[[Category: Kisselev | [[Category: Heikaus CC]] | ||
[[Category: Klevit | [[Category: Herbig E]] | ||
[[Category: Littlefield | [[Category: Kisselev L]] | ||
[[Category: Pacheco | [[Category: Klevit RE]] | ||
[[Category: Vernon | [[Category: Littlefield P]] | ||
[[Category: Warfield | [[Category: Pacheco D]] | ||
[[Category: Vernon R]] | |||
[[Category: Warfield L]] | |||
Latest revision as of 09:56, 1 May 2024
Structure of the complex of the central activation domain of Gcn4 bound to the mediator co-activator domain 1 of Gal11/med15Structure of the complex of the central activation domain of Gcn4 bound to the mediator co-activator domain 1 of Gal11/med15
Structural highlights
FunctionMED15_YEAST Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins. It has an important role in the negative regulation of Ty transcription.[1] [2] [3] See AlsoReferences
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