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==Near atomic resolution crystal structure of Sco5413, a MarR family transcriptional regulator from Streptomyces coelicolor== | |||
<StructureSection load='4b8x' size='340' side='right'caption='[[4b8x]], [[Resolution|resolution]] 1.25Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4b8x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_coelicolor Streptomyces coelicolor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B8X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B8X FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.25Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b8x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b8x OCA], [https://pdbe.org/4b8x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b8x RCSB], [https://www.ebi.ac.uk/pdbsum/4b8x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b8x ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/Q9L2A7_STRCO Q9L2A7_STRCO] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The crystal structure of Sco5413 from Streptomyces coelicolor A3(2) has been determined at 1.25 A resolution, the highest resolution reported for a MarR family transcriptional regulator. Putative orthologs are encoded by the majority of sequenced actinomycete genomes, and may play roles in regulating growth and antibiotic production, but they have yet to be assigned a precise function. Sco5413 forms a homodimer and, through comparisons with other MarR family protein structures, we postulate that it adopts a conformation compatible with DNA binding, and that a channel at the dimer interface, lined by well-conserved residues, is the binding site of an unidentified effector ligand. Proteins 2012. (c) 2012 Wiley Periodicals, Inc. | |||
High resolution crystal structure of Sco5413, a widespread actinomycete MarR family transcriptional regulator of unknown function.,Holley TA, Stevenson CE, Bibb MJ, Lawson DM Proteins. 2012 Oct 8. doi: 10.1002/prot.24197. PMID:23042442<ref>PMID:23042442</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 4b8x" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Streptomyces coelicolor]] | |||
[[Category: Bibb MJ]] | |||
[[Category: Holley TA]] | |||
[[Category: Lawson DM]] | |||
[[Category: Stevenson CEM]] | |||
Latest revision as of 13:40, 6 November 2024
Near atomic resolution crystal structure of Sco5413, a MarR family transcriptional regulator from Streptomyces coelicolorNear atomic resolution crystal structure of Sco5413, a MarR family transcriptional regulator from Streptomyces coelicolor
Structural highlights
FunctionPublication Abstract from PubMedThe crystal structure of Sco5413 from Streptomyces coelicolor A3(2) has been determined at 1.25 A resolution, the highest resolution reported for a MarR family transcriptional regulator. Putative orthologs are encoded by the majority of sequenced actinomycete genomes, and may play roles in regulating growth and antibiotic production, but they have yet to be assigned a precise function. Sco5413 forms a homodimer and, through comparisons with other MarR family protein structures, we postulate that it adopts a conformation compatible with DNA binding, and that a channel at the dimer interface, lined by well-conserved residues, is the binding site of an unidentified effector ligand. Proteins 2012. (c) 2012 Wiley Periodicals, Inc. High resolution crystal structure of Sco5413, a widespread actinomycete MarR family transcriptional regulator of unknown function.,Holley TA, Stevenson CE, Bibb MJ, Lawson DM Proteins. 2012 Oct 8. doi: 10.1002/prot.24197. PMID:23042442[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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