1a59: Difference between revisions

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-[[Image:1a59.png|left|200px]]
-{{STRUCTURE_1a59|  PDB=1a59  |  SCENE=  }}
+==COLD-ACTIVE CITRATE SYNTHASE==
+<StructureSection load='1a59' size='340' side='right'caption='[[1a59]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
-===COLD-ACTIVE CITRATE SYNTHASE===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1a59]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Antarctic_bacterium_DS2-3R Antarctic bacterium DS2-3R]. The September 2007 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Citrate Synthase''  by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2007_9 10.2210/rcsb_pdb/mom_2007_9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A59 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A59 FirstGlance]. <br>
-{{ABSTRACT_PUBMED_9551556}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.09&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a59 OCA], [https://pdbe.org/1a59 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a59 RCSB], [https://www.ebi.ac.uk/pdbsum/1a59 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a59 ProSAT]</span></td></tr>
-[[1a59]] is a 1 chain structure of [[Citrate Synthase]] with sequence from [http://en.wikipedia.org/wiki/Bacteria Bacteria]. The September 2007 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Citrate Synthase''  by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2007_9 10.2210/rcsb_pdb/mom_2007_9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A59 OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PRPC_ABDS2 PRPC_ABDS2] Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the Claisen condensation of propionyl-CoA and oxaloacetate (OAA) to yield 2-methylcitrate (2-MC) and CoA. Also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity.<ref>PMID:9310359</ref> <ref>PMID:9579066</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a5/1a59_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a59 ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Citrate Synthase|Citrate Synthase]]
+*[[Citrate Synthase 3D structures|Citrate Synthase 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:009551556</ref><ref group="xtra">PMID:014997520</ref><references group="xtra"/>
+__TOC__
-[[Category: Bacteria]]
+</StructureSection>
+[[Category: Antarctic bacterium DS2-3R]]
 [[Category: Citrate Synthase]]
+[[Category: Large Structures]]
 [[Category: RCSB PDB Molecule of the Month]]
-[[Category: Danson, M J.]]
+[[Category: Danson MJ]]
-[[Category: Gerike, U.]]
+[[Category: Gerike U]]
-[[Category: Hough, D W.]]
+[[Category: Hough DW]]
-[[Category: Russell, R J.M.]]
+[[Category: Russell RJM]]
-[[Category: Taylor, G L.]]
+[[Category: Taylor GL]]
-[[Category: Cold-activity]]