3brx: Difference between revisions

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[[Image:3brx.png|left|200px]]


{{STRUCTURE_3brx|  PDB=3brx  |  SCENE=  }}
==Crystal Structure of calcium-bound cotton annexin Gh1==
 
<StructureSection load='3brx' size='340' side='right'caption='[[3brx]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
===Crystal Structure of calcium-bound cotton annexin Gh1===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3brx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gossypium_hirsutum Gossypium hirsutum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BRX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BRX FirstGlance]. <br>
{{ABSTRACT_PUBMED_18441010}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3brx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3brx OCA], [https://pdbe.org/3brx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3brx RCSB], [https://www.ebi.ac.uk/pdbsum/3brx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3brx ProSAT]</span></td></tr>
[[3brx]] is a 1 chain structure of [[Annexin]] with sequence from [http://en.wikipedia.org/wiki/Gossypium_hirsutum Gossypium hirsutum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BRX OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/ANX1_GOSHI ANX1_GOSHI] Binds to phospholipid vesicles in a calcium-dependent manner in vitro (PubMed:16331990, PubMed:18441010). Prefers phosphatidyl-serine containing membranes. May have a role in the membrane cytoskeleton scaffolding or exocytotic processes (PubMed:16331990). May be involved in oxidative stress response (Probable).<ref>PMID:16331990</ref> <ref>PMID:18441010</ref> <ref>PMID:12787021</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/br/3brx_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3brx ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Annexin|Annexin]]
*[[Annexin 3D structures|Annexin 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:018441010</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Gossypium hirsutum]]
[[Category: Gossypium hirsutum]]
[[Category: Hofmann, A.]]
[[Category: Large Structures]]
[[Category: Hu, N J.]]
[[Category: Hofmann A]]
[[Category: Annexin]]
[[Category: Hu N-J]]
[[Category: Calcium binding]]
[[Category: Membrane binding]]
[[Category: Membrane protein]]

Latest revision as of 17:03, 13 March 2024

Crystal Structure of calcium-bound cotton annexin Gh1Crystal Structure of calcium-bound cotton annexin Gh1

Structural highlights

3brx is a 1 chain structure with sequence from Gossypium hirsutum. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.5Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ANX1_GOSHI Binds to phospholipid vesicles in a calcium-dependent manner in vitro (PubMed:16331990, PubMed:18441010). Prefers phosphatidyl-serine containing membranes. May have a role in the membrane cytoskeleton scaffolding or exocytotic processes (PubMed:16331990). May be involved in oxidative stress response (Probable).[1] [2] [3]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Dabitz N, Hu NJ, Yusof AM, Tranter N, Winter A, Daley M, Zschornig O, Brisson A, Hofmann A. Structural determinants for plant annexin-membrane interactions. Biochemistry. 2005 Dec 13;44(49):16292-300. doi: 10.1021/bi0516226. PMID:16331990 doi:http://dx.doi.org/10.1021/bi0516226
  2. ↑ Hu NJ, Yusof AM, Winter A, Osman A, Reeve AK, Hofmann A. The crystal structure of calcium-bound annexin Gh1 from Gossypium hirsutum and its implications for membrane binding mechanisms of plant annexins. J Biol Chem. 2008 Jun 27;283(26):18314-22. Epub 2008 Apr 25. PMID:18441010 doi:10.1074/jbc.M801051200
  3. ↑ Hofmann A, Delmer DP, Wlodawer A. The crystal structure of annexin Gh1 from Gossypium hirsutum reveals an unusual S3 cluster. Eur J Biochem. 2003 Jun;270(12):2557-64. PMID:12787021

3brx, resolution 2.50Å

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