3ter: Difference between revisions

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==Crystal structure of SOAR domain with Inhibition helix from C. elegans==
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<StructureSection load='3ter' size='340' side='right'caption='[[3ter]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3ter]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TER OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TER FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.551&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ter FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ter OCA], [https://pdbe.org/3ter PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ter RCSB], [https://www.ebi.ac.uk/pdbsum/3ter PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ter ProSAT]</span></td></tr>
{{STRUCTURE_3ter|  PDB=3ter  |  SCENE=  }}
</table>
 
== Function ==
===Crystal structure of SOAR domain with Inhibition helix from C. elegans===
[https://www.uniprot.org/uniprot/STIM1_CAEEL STIM1_CAEEL] Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor which upon Ca(2+) depletion, activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, orai-1. Essential for Ca (2+) and IP3-dependent contractile activity of gonad sheath cells and spermatheca. Essential for fertility. Does not play a role in posterior body wall muscle contraction (pBoc) rhythmicity, intestinal cell oscillatory Ca(2+) signaling or intestinal ER Ca(2+) hemeostasis.<ref>PMID:16966474</ref> <ref>PMID:17218360</ref>
 
== References ==
 
<references/>
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{{ABSTRACT_PUBMED_22451904}}
 
==About this Structure==
[[3ter]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TER OCA].  
 
==Reference==
<ref group="xtra">PMID:022451904</ref><references group="xtra"/>
[[Category: Caenorhabditis elegans]]
[[Category: Caenorhabditis elegans]]
[[Category: Cai, X.]]
[[Category: Large Structures]]
[[Category: Jin, H.]]
[[Category: Cai X]]
[[Category: Shen, Y.]]
[[Category: Jin H]]
[[Category: Yang, X.]]
[[Category: Shen Y]]
[[Category: Dimer]]
[[Category: Yang X]]
[[Category: Metal binding protein]]

Latest revision as of 11:37, 20 March 2024

Crystal structure of SOAR domain with Inhibition helix from C. elegansCrystal structure of SOAR domain with Inhibition helix from C. elegans

Structural highlights

3ter is a 2 chain structure with sequence from Caenorhabditis elegans. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.551Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

STIM1_CAEEL Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor which upon Ca(2+) depletion, activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, orai-1. Essential for Ca (2+) and IP3-dependent contractile activity of gonad sheath cells and spermatheca. Essential for fertility. Does not play a role in posterior body wall muscle contraction (pBoc) rhythmicity, intestinal cell oscillatory Ca(2+) signaling or intestinal ER Ca(2+) hemeostasis.[1] [2]

References

  1. ↑ Yan X, Xing J, Lorin-Nebel C, Estevez AY, Nehrke K, Lamitina T, Strange K. Function of a STIM1 homologue in C. elegans: evidence that store-operated Ca2+ entry is not essential for oscillatory Ca2+ signaling and ER Ca2+ homeostasis. J Gen Physiol. 2006 Oct;128(4):443-59. doi: 10.1085/jgp.200609611. Epub 2006 Sep , 11. PMID:16966474 doi:http://dx.doi.org/10.1085/jgp.200609611
  2. ↑ Lorin-Nebel C, Xing J, Yan X, Strange K. CRAC channel activity in C. elegans is mediated by Orai1 and STIM1 homologues and is essential for ovulation and fertility. J Physiol. 2007 Apr 1;580(Pt 1):67-85. Epub 2007 Jan 11. PMID:17218360 doi:http://dx.doi.org/jphysiol.2006.124883

3ter, resolution 2.55Å

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