Structural highlights
Function
STIM1_CAEEL Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor which upon Ca(2+) depletion, activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, orai-1. Essential for Ca (2+) and IP3-dependent contractile activity of gonad sheath cells and spermatheca. Essential for fertility. Does not play a role in posterior body wall muscle contraction (pBoc) rhythmicity, intestinal cell oscillatory Ca(2+) signaling or intestinal ER Ca(2+) hemeostasis.[1] [2]
References
- ↑ Yan X, Xing J, Lorin-Nebel C, Estevez AY, Nehrke K, Lamitina T, Strange K. Function of a STIM1 homologue in C. elegans: evidence that store-operated Ca2+ entry is not essential for oscillatory Ca2+ signaling and ER Ca2+ homeostasis. J Gen Physiol. 2006 Oct;128(4):443-59. doi: 10.1085/jgp.200609611. Epub 2006 Sep , 11. PMID:16966474 doi:http://dx.doi.org/10.1085/jgp.200609611
- ↑ Lorin-Nebel C, Xing J, Yan X, Strange K. CRAC channel activity in C. elegans is mediated by Orai1 and STIM1 homologues and is essential for ovulation and fertility. J Physiol. 2007 Apr 1;580(Pt 1):67-85. Epub 2007 Jan 11. PMID:17218360 doi:http://dx.doi.org/jphysiol.2006.124883