3v8d: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older edit
No edit summary
No edit summary
 
(7 intermediate revisions by the same user not shown)
Line 1: Line 1:
'''Unreleased structure'''


The entry 3v8d is ON HOLD  until Paper Publication
==Crystal structure of human CYP7A1 in complex with 7-ketocholesterol==
 
<StructureSection load='3v8d' size='340' side='right'caption='[[3v8d]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
Authors: Strushkevich, N., Tempel, W., MacKenzie, F., Wernimont, A.K., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Usanov, S.A., Park, H., Structural Genomics Consortium (SGC)
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3v8d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V8D FirstGlance]. <br>
Description: Crystal structure of human CYP7A1 in complex with 7-ketocholesterol
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0GV:(3BETA,8ALPHA,9BETA)-3-HYDROXYCHOLEST-5-EN-7-ONE'>0GV</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v8d OCA], [https://pdbe.org/3v8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v8d RCSB], [https://www.ebi.ac.uk/pdbsum/3v8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v8d ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CP7A1_HUMAN CP7A1_HUMAN] Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis.<ref>PMID:19965590</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Bountra C]]
[[Category: Edwards AM]]
[[Category: MacKenzie F]]
[[Category: Park H]]
[[Category: Strushkevich N]]
[[Category: Tempel W]]
[[Category: Usanov SA]]
[[Category: Weigelt J]]
[[Category: Wernimont AK]]

Latest revision as of 17:21, 14 March 2024

Crystal structure of human CYP7A1 in complex with 7-ketocholesterolCrystal structure of human CYP7A1 in complex with 7-ketocholesterol

Structural highlights

3v8d is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.9Å
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CP7A1_HUMAN Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis.[1]

References

  1. ↑ Li T, Chanda D, Zhang Y, Choi HS, Chiang JY. Glucose stimulates cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes. J Lipid Res. 2010 Apr;51(4):832-42. doi: 10.1194/jlr.M002782. Epub 2009 Oct 28. PMID:19965590 doi:http://dx.doi.org/10.1194/jlr.M002782

3v8d, resolution 1.90Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=3v8d&oldid=4099457"