Plasminogen: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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+<StructureSection load='' size='350' side='right' caption='Human glycosylated plasminogen complex with acetate, bicarbonate, K+ (purple) and Cl- (green) ions (PDB entry [[4dur]])' scene='46/465445/Cv/1'>
+== Function ==
+'''Plasmin''' (PLN) is a serine protease which is involved in degradation of fibrin clots.  PLN is released as the zymogen '''plasminogen''' (PLG) which is converted to the active PLN by a variety of enzymes.  PLN cleavage produces angiostatin.
-{{STRUCTURE_1bml|  PDB=1bml  | SIZE=400| SCENE= |right|CAPTION=Plasmin catalytic domain complex with streptokinase, [[1bml]] }}
+*'''Microplasmin''' induces posterior vitreous detachment from the retina (PVD)<ref>PMID:21099453</ref>.
-'''Plasmin''' (PLN) is a serine protease which is involved in degradation of fibrin clots.  PLN is released as the zymogen plasminogen (PLG) which is converted to the active PLN by a variety of enzymes.  PLN cleavage produces angiostatin. PLN domains are: N-terminal, C-terminal serine protease catalytic domain and 5 kringle domains of ca. 80 residues.
+== Disease ==
+PLN mutations are associated with ligneous conjunctivitis and other disorders which lead to development of pseudo membranes on mucosal surfaces<ref>PMID:19141167</ref>.
-{{TOC limit|limit=2}}
+== Structural highlights ==
+<scene name='46/465445/Cv/11'>PLN contains 7 domains</scene> which are: N-terminal, C-terminal serine protease catalytic domain and 5 kringle domains of ca. 80 residues.  The <scene name='46/465445/Cv/3'>kringle domain folds into a large loop containing 3 disulfide bonds</scene>, ''e.g.'' <scene name='46/465445/Cv/4'>Kringle 4</scene>. The kringle domain is important in protein-protein interaction with blood coagulation factors.<ref>PMID:22832192</ref>.
+*<scene name='46/465445/Cv/12'>K ion coordination site</scene>. Water molecules are shown as red spheres.
+*<scene name='46/465445/Cv/13'>Cl ion coordination site I</scene>.
+*<scene name='46/465445/Cv/14'>Cl ion coordination site II</scene>.
+*<scene name='46/465445/Cv/15'>Cl ion coordination site III</scene>.
+*<scene name='46/465445/Cv/16'>Cl ion coordination site IV</scene>.
 == 3D Structures of plasminogen ==
+[[Plasminogen 3D structures]]
+</StructureSection>
+== References ==
+<references/>
 [[Category:Topic Page]]