3ter: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older edit
m Protected "3ter" [edit=sysop:move=sysop]
No edit summary
 
(6 intermediate revisions by the same user not shown)
Line 1: Line 1:
'''Unreleased structure'''


The entry 3ter is ON HOLD
==Crystal structure of SOAR domain with Inhibition helix from C. elegans==
 
<StructureSection load='3ter' size='340' side='right'caption='[[3ter]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
Authors: Yang, X., Jin, H., Cai, X., Shen, Y.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3ter]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TER OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TER FirstGlance]. <br>
Description: Crystal structure of SOAR domain with Inhibition helix from C. elegans
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.551&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ter FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ter OCA], [https://pdbe.org/3ter PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ter RCSB], [https://www.ebi.ac.uk/pdbsum/3ter PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ter ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/STIM1_CAEEL STIM1_CAEEL] Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor which upon Ca(2+) depletion, activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, orai-1. Essential for Ca (2+) and IP3-dependent contractile activity of gonad sheath cells and spermatheca. Essential for fertility. Does not play a role in posterior body wall muscle contraction (pBoc) rhythmicity, intestinal cell oscillatory Ca(2+) signaling or intestinal ER Ca(2+) hemeostasis.<ref>PMID:16966474</ref> <ref>PMID:17218360</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Caenorhabditis elegans]]
[[Category: Large Structures]]
[[Category: Cai X]]
[[Category: Jin H]]
[[Category: Shen Y]]
[[Category: Yang X]]

Latest revision as of 11:37, 20 March 2024

Crystal structure of SOAR domain with Inhibition helix from C. elegansCrystal structure of SOAR domain with Inhibition helix from C. elegans

Structural highlights

3ter is a 2 chain structure with sequence from Caenorhabditis elegans. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.551Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

STIM1_CAEEL Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor which upon Ca(2+) depletion, activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, orai-1. Essential for Ca (2+) and IP3-dependent contractile activity of gonad sheath cells and spermatheca. Essential for fertility. Does not play a role in posterior body wall muscle contraction (pBoc) rhythmicity, intestinal cell oscillatory Ca(2+) signaling or intestinal ER Ca(2+) hemeostasis.[1] [2]

References

  1. ↑ Yan X, Xing J, Lorin-Nebel C, Estevez AY, Nehrke K, Lamitina T, Strange K. Function of a STIM1 homologue in C. elegans: evidence that store-operated Ca2+ entry is not essential for oscillatory Ca2+ signaling and ER Ca2+ homeostasis. J Gen Physiol. 2006 Oct;128(4):443-59. doi: 10.1085/jgp.200609611. Epub 2006 Sep , 11. PMID:16966474 doi:http://dx.doi.org/10.1085/jgp.200609611
  2. ↑ Lorin-Nebel C, Xing J, Yan X, Strange K. CRAC channel activity in C. elegans is mediated by Orai1 and STIM1 homologues and is essential for ovulation and fertility. J Physiol. 2007 Apr 1;580(Pt 1):67-85. Epub 2007 Jan 11. PMID:17218360 doi:http://dx.doi.org/jphysiol.2006.124883

3ter, resolution 2.55Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=3ter&oldid=4104204"