3sn7: Difference between revisions

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'''Unreleased structure'''


The entry 3sn7 is ON HOLD  until Paper Publication
==Highly Potent, Selective, and Orally Active Phosphodiestarase 10A Inhibitors==
<StructureSection load='3sn7' size='340' side='right'caption='[[3sn7]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3sn7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SN7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SN7 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.82&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=540:8-FLUORO-6-METHOXY-3,4-DIMETHYL-1-(3-METHYLPYRIDIN-4-YL)IMIDAZO[1,5-A]QUINOXALINE'>540</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sn7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sn7 OCA], [https://pdbe.org/3sn7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sn7 RCSB], [https://www.ebi.ac.uk/pdbsum/3sn7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sn7 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>


Authors: Parris, K.D.
==See Also==
 
*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
Description: Highly Potent, Selective, and Orally Active Phosphodiestarase 10A Inhibitors
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Parris KD]]

Latest revision as of 12:52, 1 March 2024

Highly Potent, Selective, and Orally Active Phosphodiestarase 10A InhibitorsHighly Potent, Selective, and Orally Active Phosphodiestarase 10A Inhibitors

Structural highlights

3sn7 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.82Å
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PDE10_HUMAN Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.[1]

See Also

References

  1. ↑ Wang H, Liu Y, Hou J, Zheng M, Robinson H, Ke H. Structural insight into substrate specificity of phosphodiesterase 10. Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):5782-7. Epub 2007 Mar 26. PMID:17389385

3sn7, resolution 1.82Å

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