3sn7

Highly Potent, Selective, and Orally Active Phosphodiestarase 10A InhibitorsHighly Potent, Selective, and Orally Active Phosphodiestarase 10A Inhibitors

Structural highlights

3sn7 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.82Å
Ligands:	, , ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PDE10_HUMAN Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.^[1]

References

↑ Wang H, Liu Y, Hou J, Zheng M, Robinson H, Ke H. Structural insight into substrate specificity of phosphodiesterase 10. Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):5782-7. Epub 2007 Mar 26. PMID:17389385

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OCA

[1] Wang H, Liu Y, Hou J, Zheng M, Robinson H, Ke H. Structural insight into substrate specificity of phosphodiesterase 10. Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):5782-7. Epub 2007 Mar 26. PMID:17389385

[1]

3sn7

Highly Potent, Selective, and Orally Active Phosphodiestarase 10A InhibitorsHighly Potent, Selective, and Orally Active Phosphodiestarase 10A Inhibitors

Structural highlights

Function

See Also

References

Contents

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3sn7

Highly Potent, Selective, and Orally Active Phosphodiestarase 10A InhibitorsHighly Potent, Selective, and Orally Active Phosphodiestarase 10A Inhibitors

Structural highlights

Function

See Also

References

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