3qj9: Difference between revisions

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==Crystal structure of fatty acid amide hydrolase with small molecule inhibitor==
The line below this paragraph, containing "STRUCTURE_3qj9", creates the "Structure Box" on the page.
<StructureSection load='3qj9' size='340' side='right'caption='[[3qj9]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3qj9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QJ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QJ9 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=QJ9:1-{(3S)-1-[4-(1-BENZOFURAN-2-YL)PYRIMIDIN-2-YL]PIPERIDIN-3-YL}-3-ETHYL-1,3-DIHYDRO-2H-BENZIMIDAZOL-2-ONE'>QJ9</scene></td></tr>
{{STRUCTURE_3qj9|  PDB=3qj9  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qj9 OCA], [https://pdbe.org/3qj9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qj9 RCSB], [https://www.ebi.ac.uk/pdbsum/3qj9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qj9 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FAAH1_RAT FAAH1_RAT] Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (By similarity).


===Crystal structure of fatty acid amide hydrolase with small molecule inhibitor===
==See Also==
 
*[[Fatty acid amide hydrolase|Fatty acid amide hydrolase]]
 
__TOC__
==About this Structure==
</StructureSection>
[[3qj9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QJ9 OCA].
[[Category: Large Structures]]
[[Category: Fatty acid amide hydrolase]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Min, X.]]
[[Category: Min X]]
[[Category: Walker, N P.C.]]
[[Category: Walker NPC]]
[[Category: Wang, Z.]]
[[Category: Wang Z]]

Latest revision as of 13:48, 21 February 2024

Crystal structure of fatty acid amide hydrolase with small molecule inhibitorCrystal structure of fatty acid amide hydrolase with small molecule inhibitor

Structural highlights

3qj9 is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.3Å
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

FAAH1_RAT Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (By similarity).

See Also

3qj9, resolution 2.30Å

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OCA
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