1zvm: Difference between revisions

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-[[Image:1zvm.png|left|200px]]
-<!--
+==Crystal structure of human CD38: cyclic-ADP-ribosyl synthetase/NAD+ glycohydrolase==
-The line below this paragraph, containing "STRUCTURE_1zvm", creates the "Structure Box" on the page.
+<StructureSection load='1zvm' size='340' side='right'caption='[[1zvm]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1zvm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZVM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZVM FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-{{STRUCTURE_1zvm|  PDB=1zvm  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zvm OCA], [https://pdbe.org/1zvm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zvm RCSB], [https://www.ebi.ac.uk/pdbsum/1zvm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zvm ProSAT]</span></td></tr>
+</table>
-===Crystal structure of human CD38: cyclic-ADP-ribosyl synthetase/NAD+ glycohydrolase===
+== Function ==
+[https://www.uniprot.org/uniprot/CD38_HUMAN CD38_HUMAN] Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
+== Evolutionary Conservation ==
-==About this Structure==
+[[Image:Consurf_key_small.gif|200px|right]]
-[[1zvm]] is a 4 chain structure of [[ADP-ribosyl cyclase 1]] and [[Cluster of Differentiation 38]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZVM OCA].
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zv/1zvm_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zvm ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[ADP-ribosyl cyclase 1]]
+*[[Cluster of Differentiation CD38|Cluster of Differentiation CD38]]
-*[[Cluster of Differentiation 38]]
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Almo, S C.]]
+[[Category: Large Structures]]
-[[Category: Sauve, A.]]
+[[Category: Almo SC]]
-[[Category: Schramm, V L.]]
+[[Category: Sauve A]]
-[[Category: Shi, W.]]
+[[Category: Schramm VL]]
-[[Category: Yang, T.]]
+[[Category: Shi W]]
-[[Category: Adpr cyclase]]
+[[Category: Yang T]]
-[[Category: Dimer]]
-[[Category: Nad hydrolase]]