Villin: Difference between revisions

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[[Image:2k6n.png|left|thumb|300px|Crystal Strcture of the Human Supervillin Headpiece, [[2k6n]]]]
<StructureSection load='' size='340' side='right' caption='Human supervillin headpiece, [[2k6n]]' scene='Villin/Cv/1' >
{{STRUCTURE_2k6n| right| PDB=2k6n  |  SCENE=Villin/Cv/1 |CAPTION=Human Supervillin Headpiece, [[2k6n]] }}
== Function ==
[[Villin]] (VIL) is an actin-binding protein. The images on the left and right correspond to one representative villin structure, ''i.e.'' the human supervillin headpiece ([[2k6n]]). It contains gelsolin-like domains in its N-terminal and a helical headpiece which binds actin. <ref>PMID:10480879</ref> Supervillin (SVIL) contains numerous gelsolin-like domains in its C-terminal and interacts with actin.  Advillin (AVIL) is another actin-binding protein in the [[gelsolin]] superfamily which is expressed in the peripheral sensory neurons.
* [[Villin]] (VIL) is an actin-binding protein.  It contains gelsolin-like domains in its N-terminal and a helical headpiece which binds actin<ref>PMID:10480879</ref>.<br />
*  '''Supervillin (SVIL)''' contains numerous gelsolin-like domains in its C-terminal and interacts with actin<ref>PMID:20309963</ref>.<br />
* '''Advillin (AVIL)''' is another actin-binding protein in the [[gelsolin]] superfamily which is expressed in the peripheral sensory neurons.<br />
*  '''Cytovillin (CVIL) or ezrin or villin-2''' serves as intermediate between plasma membrane and actin cytoskeleton<ref>PMID:8089177</ref>.  


<br />
== Relevance ==
{{TOC limit|limit=2}}
VIL immunohisochemistry is a reliable method for diagnosing microvillus inclusion disease (MVID)<ref>PMID:25517957</ref>.
</StructureSection>
== 3D Structures of Villin ==


== 3D Structures of Villin ==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
<br />
{{#tree:id=OrganizedByTopic|openlevels=0|
<br />
 
<br />
* Supervillin
<br />
 
<br />
**[[2k6m]], [[2k6n]] – hSVIL headpiece– human – NMR<br />
 
* Villin


=== Supervillin ===
**[[3fg7]] – hVIL-1 gelsolin domains 4-6<br />
**[[1unc]] – hVIL-1 headpiece<br />
**[[3iur]] - hVIL headpiece H2H3 helices + prolyl endopeptidase <br />
**[[1yu5]], [[1qqv]] - cVIL headpiece - chicken<br />
**[[2rjw]], [[2rjx]], [[2rjv]], [[2rjy]], [[1yu7]], [[1yu8]], [[3myc]], [[3mye]], [[3nkj]], [[3mya]], [[3tjw]], [[3trv]], [[3trw]], [[3try]] - cVIL-1 headpiece (mutant)<br />
**[[2llf]] - cVIL-1 gelsolin-like domain 6 - NMR<br />
**[[5i1n]], [[5i1o]], [[5i1p]], [[5i1s]] – cVIL-1 + cVIL headpiece<br />
**[[1vii]], [[2vik]], [[2vil]], [[4cz3]], [[4cz4]] - cVIL-14T headpiece - NMR<br />
**[[2ppz]], [[2jm0]] - VIL-1 headpiece (mutant) – synthetic – NMR<br />
**[[2f4k]], [[1wy3]], [[1wy4]], [[1yrf]], [[1yri]] - VIL-1 fragment (mutant) – synthetic<br />
**[[5vnt]] - VIL-4 C-terminal headpiece - ''Arabidopsis thaliana'' - NMR<br />


[[2k6m]], [[2k6n]] – hSVIL headpiece– human – NMR<br />
* Advillin


=== Villin ===
**[[1und]] – hAVIL headpiece<br />


[[3fg7]] – hVIL gelsolin domains 4-6<br />
*Cytovillin or ezrin
[[1unc]] – hVIL headpiece<br />
[[2rjw]], [[2rjx]], [[2rjv]], [[2rjy]], [[1yu7]], [[1yu8]] – cVIL headpiece (mutant) – chicken<br />
[[1yu5]], [[1qqv]] - cVIL headpiece<br />
[[1vii]], [[2vik]], [[2vil]] - cVIL headpiece - NMR<br />
[[2ppz]], [[2jm0]] - VIL headpiece (mutant) – synthetic – NMR<br />
[[2f4k]], [[1wy3]], [[1wy4]], [[1yrf]], [[1yri]] - VIL fragment (mutant) – synthetic<br />


=== Advillin ===
**[[1ni2]] – hCVIL  N terminal<br />
**[[4rm8]], [[4rm9]] – hCVIL  <br />
**[[4rma]] – hCVIL  FERM domain<br />


[[1und]] – hAVIL headpiece<br />
}}


==References==
==References==

Latest revision as of 11:29, 11 January 2021

Function

  • Villin (VIL) is an actin-binding protein. It contains gelsolin-like domains in its N-terminal and a helical headpiece which binds actin[1].
  • Supervillin (SVIL) contains numerous gelsolin-like domains in its C-terminal and interacts with actin[2].
  • Advillin (AVIL) is another actin-binding protein in the gelsolin superfamily which is expressed in the peripheral sensory neurons.
  • Cytovillin (CVIL) or ezrin or villin-2 serves as intermediate between plasma membrane and actin cytoskeleton[3].

Relevance

VIL immunohisochemistry is a reliable method for diagnosing microvillus inclusion disease (MVID)[4].

Human supervillin headpiece, 2k6n

Drag the structure with the mouse to rotate

3D Structures of Villin3D Structures of Villin

Updated on 11-January-2021

ReferencesReferences

  1. ↑ Friederich E, Vancompernolle K, Louvard D, Vandekerckhove J. Villin function in the organization of the actin cytoskeleton. Correlation of in vivo effects to its biochemical activities in vitro. J Biol Chem. 1999 Sep 17;274(38):26751-60. PMID:10480879
  2. ↑ Smith TC, Fang Z, Luna EJ. Novel interactors and a role for supervillin in early cytokinesis. Cytoskeleton (Hoboken). 2010 Jun;67(6):346-64. doi: 10.1002/cm.20449. PMID:20309963 doi:http://dx.doi.org/10.1002/cm.20449
  3. ↑ Turunen O, Wahlstrom T, Vaheri A. Ezrin has a COOH-terminal actin-binding site that is conserved in the ezrin protein family. J Cell Biol. 1994 Sep;126(6):1445-53. PMID:8089177
  4. ↑ Shillingford NM, Calicchio ML, Teot LA, Boyd T, Kurek KC, Goldsmith JD, Bousvaros A, Perez-Atayde AR, Kozakewich HP. Villin immunohistochemistry is a reliable method for diagnosing microvillus inclusion disease. Am J Surg Pathol. 2015 Feb;39(2):245-50. doi: 10.1097/PAS.0000000000000355. PMID:25517957 doi:http://dx.doi.org/10.1097/PAS.0000000000000355

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