2kuo: Difference between revisions

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-'''Unreleased structure'''
-The entry 2kuo is ON HOLD
+==Structure and identification of ADP-ribose recognition motifs of APLF and role in the DNA damage response==
+<StructureSection load='2kuo' size='340' side='right'caption='[[2kuo]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2kuo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KUO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KUO FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kuo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kuo OCA], [https://pdbe.org/2kuo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kuo RCSB], [https://www.ebi.ac.uk/pdbsum/2kuo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kuo ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/APLF_HUMAN APLF_HUMAN] Nuclease involved in single-strand and double-strand DNA break repair. Recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions. Displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage.<ref>PMID:17396150</ref> <ref>PMID:17353262</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ku/2kuo_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kuo ConSurf].
+<div style="clear:both"></div>
-Authors: Li, G.Y., McCulloch, R.D., Fenton, A., Cheung, M., Meng, L., Ikura, M., Koch, C.A.
+==See Also==
+*[[Apurinic/apyrimidinic endonuclease 3D structures|Apurinic/apyrimidinic endonuclease 3D structures]]
-Description: Structure and identification of ADP-ribose recognition motifs of APLF and role in the DNA damage response
+== References ==
+<references/>
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 10 12:57:03 2010''
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Cheung M]]
+[[Category: Fenton A]]
+[[Category: Ikura M]]
+[[Category: Koch CA]]
+[[Category: Li GY]]
+[[Category: McCulloch RD]]
+[[Category: Meng L]]