3isp: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older edit
No edit summary
No edit summary
 
(6 intermediate revisions by the same user not shown)
Line 1: Line 1:
{{Seed}}
[[Image:3isp.jpg|left|200px]]


<!--
==Crystal structure of ArgP from Mycobacterium tuberculosis==
The line below this paragraph, containing "STRUCTURE_3isp", creates the "Structure Box" on the page.
<StructureSection load='3isp' size='340' side='right'caption='[[3isp]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3isp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ISP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ISP FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3isp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3isp OCA], [https://pdbe.org/3isp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3isp RCSB], [https://www.ebi.ac.uk/pdbsum/3isp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3isp ProSAT]</span></td></tr>
{{STRUCTURE_3isp|  PDB=3isp  |  SCENE=  }}
</table>
 
== Function ==
===Crystal structure of ArgP from Mycobacterium tuberculosis===
[https://www.uniprot.org/uniprot/LYSG_MYCTU LYSG_MYCTU] Positively regulates the expression of the exporter LysE and represses its own expression. Activity requires the presence of a coinducer, lysine or histidine. Acts by binding to lysG-lysE promoter region. Also up-regulates the expression of ppsB, ppsC and ppsD, by binding to the upstream region of ppsB.<ref>PMID:29049397</ref>
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
<!--
Check<jmol>
The line below this paragraph, {{ABSTRACT_PUBMED_20036253}}, adds the Publication Abstract to the page
  <jmolCheckbox>
(as it appears on PubMed at http://www.pubmed.gov), where 20036253 is the PubMed ID number.
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/is/3isp_consurf.spt"</scriptWhenChecked>
-->
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
{{ABSTRACT_PUBMED_20036253}}
    <text>to colour the structure by Evolutionary Conservation</text>
 
  </jmolCheckbox>
==About this Structure==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3isp ConSurf].
3ISP is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ISP OCA].  
<div style="clear:both"></div>
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:20036253</ref><references group="xtra"/>
__TOC__
[[Category: Mycobacterium tuberculosis]]
</StructureSection>
[[Category: Bartlam, M.]]
[[Category: Large Structures]]
[[Category: Lou, Z.]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Rao, Z.]]
[[Category: Bartlam M]]
[[Category: Sheng, F.]]
[[Category: Lou Z]]
[[Category: Wang, H.]]
[[Category: Rao Z]]
[[Category: Zhou, X.]]
[[Category: Sheng F]]
[[Category: Dna binding domain]]
[[Category: Wang H]]
[[Category: Dna-binding]]
[[Category: Zhou X]]
[[Category: Regulatory domain]]
[[Category: Rod shaped structure]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 17 10:24:45 2010''

Latest revision as of 11:28, 20 March 2024

Crystal structure of ArgP from Mycobacterium tuberculosisCrystal structure of ArgP from Mycobacterium tuberculosis

Structural highlights

3isp is a 2 chain structure with sequence from Mycobacterium tuberculosis H37Rv. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.7Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

LYSG_MYCTU Positively regulates the expression of the exporter LysE and represses its own expression. Activity requires the presence of a coinducer, lysine or histidine. Acts by binding to lysG-lysE promoter region. Also up-regulates the expression of ppsB, ppsC and ppsD, by binding to the upstream region of ppsB.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Schneefeld M, Busche T, Geffers R, Kalinowski J, Bange FC. The transcriptional regulator LysG (Rv1985c) of Mycobacterium tuberculosis activates lysE (Rv1986) in a lysine-dependent manner. PLoS One. 2017 Oct 19;12(10):e0186505. PMID:29049397 doi:10.1371/journal.pone.0186505

3isp, resolution 2.70Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=3isp&oldid=4103794"