3isp

Crystal structure of ArgP from Mycobacterium tuberculosisCrystal structure of ArgP from Mycobacterium tuberculosis

Structural highlights

3isp is a 2 chain structure with sequence from Mycobacterium tuberculosis H37Rv. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.7Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

LYSG_MYCTU Positively regulates the expression of the exporter LysE and represses its own expression. Activity requires the presence of a coinducer, lysine or histidine. Acts by binding to lysG-lysE promoter region. Also up-regulates the expression of ppsB, ppsC and ppsD, by binding to the upstream region of ppsB.^[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Schneefeld M, Busche T, Geffers R, Kalinowski J, Bange FC. The transcriptional regulator LysG (Rv1985c) of Mycobacterium tuberculosis activates lysE (Rv1986) in a lysine-dependent manner. PLoS One. 2017 Oct 19;12(10):e0186505. PMID:29049397 doi:10.1371/journal.pone.0186505

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OCA

[1] Schneefeld M, Busche T, Geffers R, Kalinowski J, Bange FC. The transcriptional regulator LysG (Rv1985c) of Mycobacterium tuberculosis activates lysE (Rv1986) in a lysine-dependent manner. PLoS One. 2017 Oct 19;12(10):e0186505. PMID:29049397 doi:10.1371/journal.pone.0186505

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