8tvl: Difference between revisions
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==Plasminogen binding group A streptococcus M-like protein from AP53 bound to human plasminogen== | |||
<StructureSection load='8tvl' size='340' side='right'caption='[[8tvl]], [[Resolution|resolution]] 3.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8tvl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8TVL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8TVL FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.8Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8tvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8tvl OCA], [https://pdbe.org/8tvl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8tvl RCSB], [https://www.ebi.ac.uk/pdbsum/8tvl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8tvl ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PAM_STRPY PAM_STRPY] Binds to human plasminogen (and plasmin) via its kringle repeats. Also binds to albumin, immunoglobulin G and fibrinogen. Could provide the bacteria with a mechanism for invasion, as streptococcal-bound plasmin could permit tissue penetration. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Streptococcus pyogenes]] | |||
[[Category: Castellino FJ]] | |||
[[Category: McCann NR]] | |||
[[Category: Readnour BM]] | |||
[[Category: Tjia-Fleck SK]] | |||
Latest revision as of 16:16, 21 August 2024
Plasminogen binding group A streptococcus M-like protein from AP53 bound to human plasminogenPlasminogen binding group A streptococcus M-like protein from AP53 bound to human plasminogen
Structural highlights
FunctionPAM_STRPY Binds to human plasminogen (and plasmin) via its kringle repeats. Also binds to albumin, immunoglobulin G and fibrinogen. Could provide the bacteria with a mechanism for invasion, as streptococcal-bound plasmin could permit tissue penetration. |
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