8tvl

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Plasminogen binding group A streptococcus M-like protein from AP53 bound to human plasminogenPlasminogen binding group A streptococcus M-like protein from AP53 bound to human plasminogen

Structural highlights

8tvl is a 1 chain structure with sequence from Streptococcus pyogenes. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Electron Microscopy, Resolution 3.8Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PAM_STRPY Binds to human plasminogen (and plasmin) via its kringle repeats. Also binds to albumin, immunoglobulin G and fibrinogen. Could provide the bacteria with a mechanism for invasion, as streptococcal-bound plasmin could permit tissue penetration.

8tvl, resolution 3.80Å

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OCA