8k10: Difference between revisions
Jump to navigation
Jump to search
New page: '''Unreleased structure''' The entry 8k10 is ON HOLD Authors: Guo, H., Qi, C., Lu, Y., Yang, H., Zhu, Y., Sun, F., Ji, X. Description: To be published [[Category: Unreleased Structures... |
No edit summary |
||
| (3 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
==SID1 transmembrane family member 2== | |||
<StructureSection load='8k10' size='340' side='right'caption='[[8k10]], [[Resolution|resolution]] 3.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8k10]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8K10 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8K10 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8k10 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8k10 OCA], [https://pdbe.org/8k10 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8k10 RCSB], [https://www.ebi.ac.uk/pdbsum/8k10 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8k10 ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/SIDT2_HUMAN SIDT2_HUMAN] Mediates the translocation of RNA and DNA across the lysosomal membrane during RNA and DNA autophagy (RDA), a process in which RNA or DNA is directly imported into lysosomes in an ATP-dependent manner, and degraded (PubMed:27046251, PubMed:27846365). Involved in the uptake of single-stranded oligonucleotides by living cells, a process called gymnosis (PubMed:28277980). In vitro, mediates the uptake of linear DNA more efficiently than that of circular DNA, but exhibits similar uptake efficacy toward RNA and DNA. Binds long double-stranded RNA (dsRNA) (500 - 700 base pairs), but not dsRNA shorter than 100 bp (By similarity).[UniProtKB:Q8CIF6]<ref>PMID:27046251</ref> <ref>PMID:27846365</ref> <ref>PMID:28277980</ref> | ||
[[Category: | == References == | ||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Guo H]] | |||
[[Category: Ji X]] | |||
[[Category: Lu Y]] | |||
[[Category: Qi C]] | |||
[[Category: Sun F]] | |||
[[Category: Yang H]] | |||
[[Category: Zhu Y]] | |||
Latest revision as of 11:41, 14 July 2024
SID1 transmembrane family member 2SID1 transmembrane family member 2
Structural highlights
FunctionSIDT2_HUMAN Mediates the translocation of RNA and DNA across the lysosomal membrane during RNA and DNA autophagy (RDA), a process in which RNA or DNA is directly imported into lysosomes in an ATP-dependent manner, and degraded (PubMed:27046251, PubMed:27846365). Involved in the uptake of single-stranded oligonucleotides by living cells, a process called gymnosis (PubMed:28277980). In vitro, mediates the uptake of linear DNA more efficiently than that of circular DNA, but exhibits similar uptake efficacy toward RNA and DNA. Binds long double-stranded RNA (dsRNA) (500 - 700 base pairs), but not dsRNA shorter than 100 bp (By similarity).[UniProtKB:Q8CIF6][1] [2] [3] References
|
| ||||||||||||||||||