6whk: Difference between revisions

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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6whk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6whk OCA], [https://pdbe.org/6whk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6whk RCSB], [https://www.ebi.ac.uk/pdbsum/6whk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6whk ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6whk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6whk OCA], [https://pdbe.org/6whk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6whk RCSB], [https://www.ebi.ac.uk/pdbsum/6whk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6whk ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/B4UPF7_9INFA B4UPF7_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[HAMAP-Rule:MF_04072][SAAS:SAAS01039073]  Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[RuleBase:RU003324]


==See Also==
==See Also==

Latest revision as of 11:26, 17 October 2024

Minimally mutated anti-influenza broadly neutralizing antibodyMinimally mutated anti-influenza broadly neutralizing antibody

Structural highlights

6whk is a 3 chain structure with sequence from Homo sapiens and Influenza A virus (A/Beijing/262/1995(H1N1)). Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.6Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

See Also

6whk, resolution 2.60Å

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OCA
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