Bromodomain-containing protein 3D structures

3D Structures of bromodomain-containing protein3D Structures of bromodomain-containing protein

Updated on 24-December-2024

{"openlevels":0}

• Bromodomain-containing protein 1;Domains – PHD1 zinc finger 208-269; PHD2 zinc finger 317-394; bromodomain 1 555-688; PWWP 925-1049
  • 2ku3 – hBRD1 PHD1 zinc finger domain - human - NMR
    
  • 2lq6 – hBRD1 PHD2 zinc finger domain (mutant) - NMR
    
  • 3l43 – histone H3.3 N-terminal/hBRD1 PHD1 zinc finger domain - NMR
    
  • 3rcw, 4z02 – hBRD1 bromodomain
    
  • 5pwb, 5pwa, 5pw9, 5pw8, 5pw7, 5pw6, 5pw5, 5pw4, 5pw3, 5pw2, 5pw1, 5pw0, 5pvz, 5pvy, 5pvx, 5pvw, 5pvv, 5pvu, 5pvt, 5pvs, 5pvr, 5pvq, 5pvp, 5pvo, 5pvn, 5pvm, 5pvl, 5pvk, 5pvj, 5pvi, 5pvh, 5pvg, 5pvf, 5pve, 5pvd, 5pvc, 5pvb, 5pva, 5pv9, 5pv8, 5pv7, 5pv6, 5pv5, 5pv4, 5pv3, 5pv2, 5pv1, 5pv0, 5puz, 5puy, 5pux, 5puw, 5puv, 5puu, 5put, 5pus, 5pur, 5puq, 5pup, 5pun, 5pum, 5puo, 5pul, 5puk, 5puj, 5pui, 5puh, 5pug, 5puf, 5pue, 5pud, 5puc, 5pub, 5pua, 5pu9, 5pu8, 5pu7, 5pu6, 5pu5, 5pu4, 5pu3, 5pu2, 5pu1, 5pu0, 5ptz, 5pty, 5ptx, 5ptw, 5ptv, 5ptu, 5pts, 5ptt, 5ptr, 5ptq, 5ptp, 5pto, 5ptn, 5ptm, 5ptl, 5ptk, 5ptj, 5pth, 5ptg, 5ptf, 5pte, 5ptd, 5ptc, 5ptb, 5pta, 5pt9, 5pt8, 5pt7, 5pt0, 5pt1, 5pt2, 5pt3, 5pt4, 5pt5, 5pt6, 5pnx, 5pq0, 5pq1, 5pq2, 5pq3, 5pq4, 5pq5, 5pq6, 5pq7, 5pq8, 5pq9, 5pqa, 5pqb, 5pqc, 5pqd, 5pqe, 5pqf, 5pqg, 5pqh, 5pqi, 5pqj, 5pqk, 5pql, 5pqm, 5pqn, 5pqo, 5pqp, 5pqq, 5pqr, 5pqs, 5pqt, 5pqu, 5pqv, 5pqw, 5pqx, 5pqy, 5pqz, 5pr0, 5pr1, 5pr2, 5pr3, 5pr4, 5pr5, 5pr6, 5pr7, 5pr8, 5pr9, 5pra, 5prb, 5prc, 5prd, 5pre, 5prf, 5prg, 5prh, 5pri, 5prj, 5prk, 5prl, 5prm, 5prn, 5pro, 5prp, 5prq, 5prr, 5prs, 5prt, 5pru, 5prv, 5prw, 5prx, 5pry, 5prz, 5ps0, 5ps1, 5ps2, 5ps3, 5ps4, 5ps5, 5ps6, 5ps7, 5ps8, 5ps9, 5psa, 5psb, 5psc, 5psd, 5pse, 5psf, 5psg, 5psh, 5psi, 5psj, 5psk, 5psl, 5psm, 5psn, 5pso, 5psp, 5psq, 5psr, 5pss, 5pst, 5psu, 5psv, 5psw, 5psx, 5psy, 5psz - hBRD1 residues 555-668 (mutant)
    
  • 5n49 – hBRD1 bromodomain + inhibitor
    
  • 5pny, 5pnz, 5po0, 5po1, 5po2, 5po3, 5po4, 5po5, 5po6, 5po7, 5po8, 5po9, 5poa, 5pob, 5poc, 5pod, 5poe, 5pof, 5pog, 5poh, 5poi, 5poj, 5pok, 5pol, 5pom, 5pon, 5poo, 5pop, 5poq, 5por, 5pos, 5pot, 5pou, 5pov, 5pow, 5pox, 5poy, 5poz, 5pp0, 5pp1, 5pp2, 5pp3, 5pp4, 5pp5, 5pp6, 5pp7, 5pp8, 5pp9, 5ppa, 5ppb, 5ppc, 5ppd, 5ppe, 5ppf, 5ppg, 5pph, 5ppi, 5ppj, 5ppk, 5ppl, 5ppm, 5ppn, 5ppo, 5ppp, 5ppq, 5ppr, 5pps, 5ppt, 5ppu, 5ppv, 5ppw, 5ppx, 5ppy, 5ppz – hBRD1 bromodomain (mutant) + inhibitor
    
  • 5ame – hBRD1 bromodomain+PHD (mutant) + piperazine derivative
    
  • 5amf – hBRD1 bromodomain+PHD (mutant) + indazole derivative
    
  • 5fg6 – hBRD1 bromodomain+PHD + probe
    
  • 3lyi – hBRD1 PWWP domain
    
  • 7lh9 – hBRD1 PWWP domain + DNA
    
  • 4z02 – hBRD1 PWWP domain + quinoline derivative
    
• Bromodomain-containing protein 2
  • 1x0j, 2dvv – hBRD2 bromodomain 1
    
  • 5hel, 5hem, 5hen, 5hfq – hBRD2 bromodomain 1 (mutant)
    
  • 2g4a – hBRD2 residues 1-116 - NMR
    
  • 6cui – hBRD2 residues 621-750 - NMR
    
  • 5ibn – hBRD2 bromodomain 2
    
  • 4qeu, 5dfb – hBRD2 bromodomain 2 (mutant)
    
• Bromodomain-containing protein 2 complex
  • 2dvq, 2dvr, 2dvs, 2e3k, 8sb6 – hBRD2 bromodomain 1 + histone H4 peptide
    
  • 6u61, 6u8h, 6ulq – hBRD2 bromodomain 1 + peptide
    
  • 3oni – hBRD2 residues 224-335 + inhibitor
    
  • 3aqa, 2ydw, 2yek, 4a9e, 4a9f, 4a9h, 4a9i, 4a9j, 4a9m, 4a9n, 4a9o, 4alh, 4akn, 4alg, 4uyf, 4uyg, 4uyh, 6db0, 6ddi, 6jke, 6k05, 6ony, 6tq2, 7dpn, 7dpo, 7env, 7lah, 7lai, 7laj, 7lau, 7lay, 7npy, 7mpz, 7nq0, 7nq1, 7nq2,7nq3, 7nq5, 7nq7, 7nq8, 7nq9, 7nqi, 7nqj, 7oe4, 7oe5, 7oe6, 7oe8, 7oe9, 7oep, 7oer, 7oes, 7oet, 7ogy, 7usi – hBRD2 bromodomain 1 + inhibitor
    
  • 7lak – hBRD2 bromodomain 1 + drug
    
  • 7vrh, 7vrk, 7vro, 7vrz, 7vsf – hBRD2 bromodomain 1 + purine derivative
    
  • 4mr5, 4mr6, 4j1p, 5ig6, 5ek9, 5dw1, 5xhk, 5xhe, 5u6v, 5n2l, 6mo7, 6mo8, 6mo9, 6moa, 6dbc, 6ddj, 6e6j, 6ffe, 6fff, 6ffg, 6k04, 6swo, 6swp, 6viy, 6wwb, 6z7f, 6z8p, 6zb0, 6zb1, 6zb2, 7enz, 7eo5, 7l6d, 7l72, 7l9g, 7l9j, 7l9k, 7lbt, 7npz, 7nq5, 7nq7, 7nq8, 7nq9, 7nqi, 7nqj, 7nqi, 7q5o, 7usg, 7wln, 7wmq, 7wmu, 7wn5, 7wna, 7wni, 8b5g, 8b5h, 8b5i, 8b5j, 8px8, 8wyg, 9fbx – hBRD2 bromodomain 2 + inhibitor
    
  • 5o3i, 5o3h, 5o3g, 5o3f, 5o3e, 5o3d, 5o3c, 5o3b, 5o3a, 5o39, 5o38, 6ytm – hBRD2 bromodomain 2 (mutant) + inhibitor
    
  • 7vri, 7vrm, 7vrq, 7vs0, 7vs1 – hBRD2 bromodomain 2 + purine derivative
    
  • 6u71, 6ult, 7jx7, 8cv7, 8dnq – hBRD2 bromodomain 2 + peptide
    
  • 5u5s – hBRD2 bromodomain 2 + STAT3 peptide - NMR
    
  • 5bt5, 8px2– hBRD2 bromodomain 2 + probe
    
  • 4qev, 4qew – hBRD2 bromodomain 2 (mutant) + probe
    
  • 7uu0 – hBRD2 bromodomain 2 + ligand
    
  • 5dfc, 5dfd – hBRD2 bromodomain 2 (mutant) + ligand
    
• Bromodomain-containing protein 3; domains – bromodomain 1 24-244; bromodomain 2 307-416; ET 554-640
  • 2nxb – hBRD3 bromodomain 1
    
  • 2yw5 – hBRD3 bromodomain 1 - NMR
    
  • 3s91, 3s92, 6qju, 7laz – hBRD3 bromodomain 1 + inhibitor
    
  • 7r8r – hBRD3 bromodomain 1 + physachenolide
    
  • 6u4a, 7rjk, 7rjl, 7rjm, 7rjn, 7to7, 7to9, 7toa – hBRD3 bromodomain 1 + peptide
    
  • 2oo1 – hBRD3 bromodomain 2
    
  • 2e7n – hBRD3 bromodomain 2 - NMR
    
  • 5hfr – hBRD3 bromodomain 2 (mutant)
    
  • 5hjc, 6ulp, 8cv5, 8b5a – hBRD3 bromodomain 2+ peptide
    
  • 5a7c, 7l9l, 7lb4, 7s3p, 7ug5 – hBRD3 bromodomain 2 + inhibitor
    
  • 7jmy – hBRD3 ET domain - NMR
    
  • 6bgg, 6bgh, 7jq8, 7jyn, 7jyz – hBRD3 ET domain + peptide - NMR
    
  • 2l5e – mBRD3 bromodomain 1 + GATA-1 C-terminal – mouse - NMR
    
• Bromodomain-containing protein 4
  • 2oss, 4j3i, 4lyi, 5hq7, 5hq6, 5hq5, 8ibq – hBRD4 bromodomain 1
    
  • 2ouo – hBRD4 bromodomain 2
    
  • 2i8n – hBRD4 bromodomain 2 - NMR
    
  • 3jvj – mBRD4 bromodomain 1
    
  • 2dww, 3jvl, 3jvm – mBRD4 bromodomain 2
    
  • 2jns – mBRD4 ET domain - NMR
    
• Bromodomain-containing protein 4 complex
  • 6dne – hBRD4 + inhibitor
    
  • 8ov6 – hBRD4 + DCAF16 + DDB1 - Cryo EM
    
  • 8g46 – hBRD4 + DCAF16 + DDB1 + DET1 - Cryo EM
    
• Bromodomain-containing protein 4 bromodomain 1 residues 44-168 complex
  • 2yel, 3p5o, 3svf, 3svg, 3u5j, 3u5k, 3u5l, 3zyu, 4a9l, 4bjx, 4bw1, 4bw2, 4bw3, 4bw4, 4c66, 4c67, 4cfk, 4cfl, 4cl9, 4clb, 4don, 4e96, 4f3i, 4gpj, 4hxk, 4hxl, 4hxm, 4hxn, 4hxo, 4hxp, 4hxr, 4hxs, 4hbv, 4hbw, 4hbx, 4hby, 4ioo, 4ioq, 4ior, 4j0r, 4j0s, 4lr6, 4lrg, 4lyw, 4lzs, 4men, 4meo, 4mep, 4meq, 4mr3, 4mr4, 4nqm, 4nr8, 4nuc, 4nue, 4nud, 4o70, 4o71, 4o72, 4o74, 4o75, 4o76, 4o77, 4o78, 4o7a, 4o7b, 4o7c, 4o7e, 4o7f, 4ogi, 4ogj, 4pce, 4pci, 4ps5, 4qr3, 4qr4, 4qr5, 4qzs, 4uix, 4uiy, 4uiz, 4uyd, 4wiv, 4x2i, 4xy9, 4xya, 4yh3, 4yh4, 4z1q, 4z1s, 4zc9, 4zw1, 5a5s, 5a85, 5acy, 5ad2, 5ad3, 5bt4, 5cfw, 5coi, 5cp5, 5cpe, 5cqt, 5crm, 5crz, 5cs8, 5ctl, 5cy9, 5d0c, 5d24, 5d25, 5d26, 5d3h, 5d3j, 5d3l, 5d3n, 5d3p, 5d3r, 5d3s, 5d3t, 5dlx, 5dlz, 5dw2, 5dx4, 5e0r, 5egu, 5ei4, 5eis, 5f5z, 5f60, 5f61, 5f62, 5f63, 5fbx, 5h21, 5hls, 5hm0, 5kdh, 5kj0, 5ku3, 5khm, 5i80, 5i88, 5lj1, 5lj2, 5lrq, 5luu, 5m39, 5m3a, 5mkz, 5mli, 5n2m, 5o97, 5ovb, 5ti7, 5u2f, 5u2e, 5u28, 5ula, 5v67, 5vom, 5uvw, 5vbo, 5vbp, 5vzs, 5w55, 5wa5, 5wma, 5wuu, 5xhy, 5xi2, 5xi3, 5xi4, 5y1y, 5y93, 5y94, 5y8c, 5y8w, 5y8y, 5y8z, 5yqx, 5z1r, 5z1s, 5z1t, 5z5t, 5z5u, 5z5v, 5z8g, 5z8r, 5z8z, 5z90, 5z9k, 6afr, 6ajv, 6ajw, 6ajx, 6ajy, 6cd4, 6cd5, 6cis, 6ciy, 6cj1, 6cj2, 6ckr, 6cks, 6czu, 6czv, 6djc, 6dl2, 6dmj, 6dml, 6e4a, 6fnx, 6fo5, 6fsy, 6ft3, 6ft4, 6hdq, 6i7x, 6i7y, 6in1, 6in2, 6ji3, 6ji4, 6ji5, 6jj3, 6jj5, 6jj6, 6jjb, 6kec, 6ked, 6kee, 6kef, 6keg, 6keh, 6kei, 6kej, 6kek, 6lg4, 6lg5, 6lg6, 6lg7, 6lg8, 6lg9, 6lih, 6lim, 6mau, 6mh1, 6mh7, 6p05, 6prt, 6ps9, 6psb, 6q3y, 6q3z, 6rwj, 6s25, 6s4b, 6s6k, 6sb8, 6se4, 6swn, 6swq, 6tpx, 6tpy, 6tpz, 6tq1, 6u0d, 6uvj, 6uvm, 6uwu, 6uwx, 6v0u, 6v1k, 6v1l, 6v1u, 6viw, 6vix, 6viz, 6vub, 6vuc, 6vuf, 6vuj, 6wgx, 6ww8, 6x7b, 6x7c, 6x7d, 6xv7, 6xvc, 6wvx, 6yin, 6yqn, 6yqo, 6yqp, 6z7g, 6z7l, 6z7m, 6zci, 6zed, 6zel, 6zf9, 7c2z, 7a9u, 7ajn, 7axr, 7b1t, 7c6p, 7dhs, 7ehw, 7ehy, 7eig, 7eik, 7eil, 7fh2, 7k6g, 7k6h, 7khl, 7kkw, 7jkw, 7jkx, 7jky, 7l9m, 7la9, 7lh8, 7m16, 7mce, 7mcf, 7mlq, 7mlr, 7mls, 7mr5, 7mr6, 7mr7, 7mr8, 7mr9, 7mra, 7mrb, 7rn2, 7o18, 7oeo, 7p6v, 7p6w, 7p6y, 7q3f, 7qdl, 7r5b, 7r9c, 7rek, 7rel, 7rem, 7rmd, 7rui, 7rxr, 7rxs, 7rxt, 7t3f, 7ugf, 7uty, 7uzn, 7v1u, 7v2j, 7w3d, 7wjs, 7wky, 7wl4, 7wwz, 7x6t, 6xuz, 7yl2, 7ymg, 7yq9, 8b96, 8b98, 8c11, 8ckf, 8dyr, 8e17, 8e3w, 8ead, 8fvk, 8gpz, 8gq0, 8k14, 8p9f, 8p9g, 8p9h, 8p9i, 8p9j, 8p9k, 8p9l, 8piq, 8pxa, 8pxm, 8pxn, 8q34, 8qal, 8qan, 8qap, 8qar, 8v9f, 8wiu, 8wqo, 8wxy, 8wy3, 8wy7, 8wyp, 9f1j, 9f1k, 9f1l, 9f1m, 9f1n, 9fwx, 9fxp – hBRD4 bromodomain 1 + inhibitor
    
  • 5ti6, 5ti5, 5ti4, 5ti3, 5ti2, 5you, 5yov, 5wmd, 5wmg, 6g0d, 6g0e, 6g0f, 6g0g, 6g0h, 6hov – hBRD4 bromodomain 1 (mutant) + inhibitor
    
  • 7z9w, 7z9y, 7za6, 7za7, 7za8, 7za9, 7zaa, 7zad, 7zae, 7zaj, 7zaq, 7zar, 7zat, 7ze6, 7ze7, 7zef, 7zen, 7zfn, 7zfo, 7zfs, 7zft, 7zfu, 7zfv, 7zfy, 7zfz, 7zg1, 7zg2 – hBRD4 bromodomain 1 + FragLite
    
  • 5z9c – hBRD4 bromodomain 1 + inhibitor - NMR
    
  • 4lys, 4lzr, 6ajz – hBRD4 bromodomain 1 + colchiceine
    
  • 4qb3 – hBRD4 bromodomain 1 + olinone
    
  • 4whw – hBRD4 bromodomain 1 + probe
    
  • 5igk – hBRD4 bromodomain 1 + bromosporine
    
  • 5hcl – hBRD4 bromodomain 1 + drug
    
  • 6u6k, 6u72, 6u74, 6u8m, 6uls, 6ulv – hBRD4 bromodomain 1 + cyclic peptide
    
  • 6bn7, 6bn8, 6bn9, 6bnb, 6boy – hBRD4 bromodomain 1 (mutant) + DNA damage-binding protein + cereblon
    
  • 7khh, 7znt, 8bds, 8beb – hBRD4 bromodomain 1 + elongin-B + elongin-C + PVHL peptide + inhibitor
    
  • 3uvw, 3uvy, 3uvx, 3uw9, 8b5b, 8b5c – hBRD4 bromodomain 1 + histone H4 peptide
    
  • 7tuq, 7tv0 – hBRD4 bromodomain 1 + SARS peptide
    
  • 4kv1, 5nng, 5nnf, 5nne, 5nng, 5nnf, 5nne, 6g0o, 6g0p, 7rjo, 7rjp, 7rjq, 7rjr, 7to8 – hBRD4 bromodomain 1 + peptide
    
  • 8ewv – hBRD4 bromodomain 1 + elongin-B + elongin-C + PVHL peptide
    
  • 6bnh – hBRD4 ET domain + JMJD6 peptide - NMR
    
  • 3mxf – mBRD4 bromodomain 1 + inhibitor
    
  • 3jvk, 3muk, 3mul, 5nnd, 5nnc – mBRD4 bromodomain 1 + histone H3.3 peptide
    
• Bromodomain-containing protein 4 bromodomain 2 residues 344-455 complex
  • 7usk – hBRD4 bromodomain 2
    
  • 2yem, 4z93, 5u2c, 5jwm, 5uvz, 5uvy, 5uvx, 5uvv, 5uvu, 5uvt, 5uvs, 5uoo, 5uf0, 5uez, 5uey, 5uex, 5uew, 5uev, 5ueu, 5uet, 5ues, 5uer, 5ueq, 5uep, 5ueo, 6ffd, 6ffe, 6ffg, 6c7q, 6c7r, 6duv, 6i80, 6i81, 6zb3, 7c6p, 7jkz, 7ko0, 7ruh, 7ush, 7usj, 8idh, 8zmq, 9fby – hBRD4 bromodomain 2 + inhibitor
    
  • 7aqt – hBRD4 bromodomain 2 + inhibitor - NMR
    
  • 2lsp – hBRD4 bromodomain 2 + Nf-Kb peptide
    
  • 4kv4 – hBRD4 bromodomain 2 + Rel peptide
    
  • 2mjv – hBRD4 bromodomain 2 + Twist peptide
    
  • 6mnl – hBRD4 bromodomain 2 + foxo3a peptide
    
  • 6ko2 – hBRD4 bromodomain 2 + histone peptide
    
  • 6u6l, 6u8g, 6u8i – hBRD4 bromodomain 2 + cyclic peptide
    
  • 5t35, 6sis, 8bdt, 8bdx – hBRD4 bromodomain 2 + elongin-B + elongin-C + PVHL peptide
    
  • 8rwz – hBRD4 bromodomain 2 + elongin-B + elongin-C + PVHL peptide + cullin + RBX1 – Cryo EM
    
  • 8r5h – hBRD4 bromodomain 2 in cullin ring ligase – Cryo EM
    
• Bromodomain-containing protein 7
  • 6ppa – hBRD7 bromodomain
    
  • 5mq1, 6v0q, 6v16, 6v17, 6v1e, 6v1f, 6v1h – hBRD7 bromodomain + inhibitor
    
  • 7y84 – hBRD7 in nucleosome PBAF complex – Cryo EM
    
• Bromodomain-containing protein 9
  • 3hme, 6uzf – hBRD9 bromodomain
    
  • 5ji8 – hBRD9 JUS-SPRY domain
    
  • 5ign – hBRD9 bromodomain + L999
    
  • 5igm – hBRD9 bromodomain + bromosporine
    
  • 6v0x – hBRD9 bromodomain + sunitinib
    
  • 4nqn, 4xy8, 4z6h, 4z6i, 5e9v, 5f2p, 5f25, 5f1l, 5f1h, 5eu1, 5mky, 6hm0, 6bqa, 6v0s, 6v14, 6v1b, 6y7h, 6y7j, 6y7k, 6y7i, 6y7l, 6yqr, 6yqs, 6yqw, 6yqz, 8a71, 8a7i, 8ahc – hBRD9 bromodomain + inhibitor
    
  • 4yy4 – hBRD9 bromodomain + DMSO
    
  • 4yy6, 4yyd, 4yyg, 4yyh, 4yyj, 4yyk, 4yyi – hBRD9 bromodomain + histone H4 peptide
    
  • 4uit, 4uiu, 4uiv, 4uiw – hBRD9 JUS-SPRY domain + inhibitor
    
  • 5i7y, 5i7x, 5i40 – hBRD9 JUS-SPRY domain + inhibitor
    
  • 5twx – hBRD9 bromodomain residues 134-250 + heterobifunctional ligand