NADPH dehydrogenase: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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-<StructureSection load='1oyb' size='340' side='right' caption='Structure of yeast NADPH dehydrogenase complex with FMN and p-hydroxybenzaldehyde (PDB code [[1oyb]]).' scene=''>
+<StructureSection load='1k03' size='350' side='right' caption='Structure of yeast NADPH dehydrogenase complex with FMN, p-hydroxybenzaldehyde and Mg+2 ion (green) (PDB code [[1k03]]).' scene='59/595221/Cv/1'>
 == Function ==
-'''NADPH dehydrogenase''' or '''old yellow enzyme''' (OYE) catalyzes the conversion of NADPH, H+ and acceptor to NADP+ and reduced acceptor<ref>PMID:12803488</ref>.  See  [[NAD(P)H]].  The acceptor is a quinone.  OYE is a flavoenzyme with two cofactors: FAD and FMN.
+'''NADPH dehydrogenase''' or '''old yellow enzyme''' or '''NADH:flavin oxidoreductase/NADH oxidase''' or '''prostaglandin F2A synthase''' or '''chromate reductase''' (OYE) catalyzes the conversion of NADPH, H+ and acceptor to NADP+ and reduced acceptor<ref>PMID:12803488</ref>.  See  [[NAD(P)H]].  The acceptor is a quinone.  OYE is a flavoenzyme with two cofactors: FAD and FMN.
+*'''NADPH dehydrogenase quinone 1''' (NQO1) reduces quinones to hydroquinones.
+*'''NADPH dehydrogenase quinone 2''' (NQO2) catayzes electron transfer from NADH to ubiquinone in the mitochondrial respiratory chain<ref>PMID:23086143</ref>.
 == Structural highlights ==
-OYE cofactor FMN interacts with the ligand<ref>PMID:11668181</ref>.
+<scene name='59/595221/Cv/5'>OYE cofactor FMN interacts with the ligand in active site</scene><ref>PMID:11668181</ref>. Water molecules are shown as red spheres.
 </StructureSection>
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 *NADPH dehydrogenase
-**[[1oyc]], [[1oya]], [[4rnu]], [[4rnw]], [[4rnx]] – yOYE + FMN - yeast<br />
+**[[7blf]] – OYE + FMN - fungus<br />
-**[[1k02]], [[4h6k]], [[4k7y]] – yOYE (mutant) + FMN  <br />
+**[[1oyc]], [[1oya]] – yOYE + FMN - yeast<br />
-**[[1bwk]], [[1bwl]] – OYE (mutant) + FMN  - ''Candida albicans''<br />
+**[[1oyb]] – yOYE + FMN + p-hydroxybenzaldehyde <br />
+**[[3tjl]] – SsOYE + FMN + malonate - ''Scheffersomyces stipitis'' <br />
+**[[6s32]] – OYE + FMN + benzamidine – ''Chroococcidiopsis thermalis''<br />
+**[[6s31]] – GsOYE + FMN + benzaldehyde – ''Galdieria sulphuraria''<br />
+**[[6s0g]], [[6s23]] – GsOYE + FMN <br />
+**[[6agz]] – OYE + FMN - ''Pichia''<br />
+**[[3kru]], [[3krz]] – OYE + FMN – ''Thermoanaerobacter pseudethanolicus''<br />
+**[[3atz]] – TcOYE + FMN + benzaldehyde – ''Trypanosoma cruzi''<br />
+**[[3aty]] – TcOYE + FMN <br />
+**[[2gou]], [[2gqa]] – SoOYE + FMN – ''Shewanella oneidensis''<br />
+**[[2gq9]] – SoOYE + FMN + benzaldehyde <br />
+**[[7o0t]] – OYE + FMN – ''Chloroflexus aggregans''<br />
+**[[3hgj]] – TsOYE + FMN + benzaldehyde – ''Thermus scotoductus''<br />
+**[[3hf3]] – TsOYE + FMN <br />
+*NADPH dehydrogenase 1
+**[[4rnu]], [[4rnw]], [[4rnx]] – yOYE 1 + FMN <br />
+**[[1k02]], [[4h6k]], [[4k7y]] – yOYE 1 (mutant) + FMN  <br />
+**[[1bwk]], [[1bwl]] – OYE 1 (mutant) + FMN  - ''Candida albicans''<br />
 **[[3gr7]], [[3gr8]] – OYE + FMN – ''Geobacillus kaustophilus''<br />
-**[[4qai]] – SsOYE + FMN – ''Scheffersomyces stipitis''<br />
+**[[4rnv]], [[5v4p]] – yOYE 1 + FMN + p-hydroxybenzaldehyde <br />
+**[[1k03]] – yOYE 1 (mutant) + FMN + p-hydroxybenzaldehyde <br />
+**[[3rnd]] – yOYE 1 mutant) + FMN + hydroxymethyl cyclopent-2-en-one <br />
+**[[4yil]], [[4ync]] – yOYE 1 (mutant) + FMN + acrylate derivative <br />
+**[[4gbu]], [[4gxm]] – yOYE 1 (mutant) + FMN + methyl propenyl phenol <br />
+**[[4ge8]], [[3txz]], [[4gwe]], [[4h4i]], [[4k7v]], [[4k8e]], [[4k8h]] – yOYE 1 (mutant) + FMN + carvone <br />
+**[[3tx9]] – yOYE 1 + FMN + hydroxymethyl cyclopent-2-en-one <br />
+*NADPH dehydrogenase 2.6
+**[[4qai]] – SsOYE 2.6 (mutant) + FMN <br />
+**[[4m5p]] – SsOYE 2.6 + FMN + malonate <br />
+**[[3upw]] – SsOYE 2.6 + FMN + malonate + nicotineamide<br />
+**[[4df2]] – SsOYE 2.6 + FMN + malonate + chlorophenol<br />
+*NADPH dehydrogenase 3
+**[[5v4p]] – yOYE 3 + FMN + p-hydroxybenzaldehyde <br />
+**[[5v4v]] – yOYE 3 + FMN + nicotinamide <br />
+*NADPH dehydrogenase 4
+**[[4b5n]] – SoOYE 4 + FMN <br />
-*NADPH dehydrogenase complexes
+*NADPH dehydrogenase quinone 1
-**[[1oyb]], [[4rnv]] – yOYE + FMN + p-hydroxybenzaldehyde <br />
+**[[5a4k]] – hNQO1 (mutant) + FAD - human <br />
-**[[1k03]] – yOYE (mutant) + FMN + p-hydroxybenzaldehyde <br />
+**[[5fuq]], [[4cet]] – hNQO1 (mutant) + FAD + dicoumarol <br />
-**[[3rnd]] – yOYE (mutant) + FMN + hydroxymethyl cyclopent-2-en-one <br />
+**[[4cf6]] – hNQO1 (mutant) + FAD + cibacron blue <br />
-**[[4gbu]], [[4gxm]] – yOYE (mutant) + FMN + methyl propenyl phenol <br />
-**[[4ge8]], [[3txz]], [[4gwe]], [[4h4i]], [[4k7v]], [[4k8e]], [[4k8h]] – yOYE (mutant) + FMN + carvone <br />
-**[[3tx9]] – yOYE + FMN + hydroxymethyl cyclopent-2-en-one <br />
-**[[3tjl]], [[4m5p]] – SsOYE + FMN + malonate <br />
-**[[3upw]] – SsOYE + FMN + malonate + nicotineamide<br />
-**[[4df2]] – SsOYE + FMN + malonate + chlorophenol<br />
 }}