4mal: Difference between revisions
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<StructureSection load='4mal' size='340' side='right'caption='[[4mal]], [[Resolution|resolution]] 2.05Å' scene=''> | <StructureSection load='4mal' size='340' side='right'caption='[[4mal]], [[Resolution|resolution]] 2.05Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4mal]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4mal]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MAL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MAL FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mal FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mal OCA], [https://pdbe.org/4mal PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mal RCSB], [https://www.ebi.ac.uk/pdbsum/4mal PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mal ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/FIMV_PSEAE FIMV_PSEAE] Inner membrane hub protein that plays both cAMP-dependent and cAMP-independent roles in twitching motility (PubMed:27297880, PubMed:28583947). Regulates intracellular cyclic AMP (cAMP) levels through the activation of adenylate cyclase CyaB (PubMed:20345659). Plays an essential role in a number of virulence mechanisms including type IV pilus (T4P)-mediated assembly and twitching motility as well as cAMP-dependent virulence gene expression (PubMed:10846211, PubMed:21097635). Mediates also type II secretion (T2S) of lipases and proteases (PubMed:21527471). In addition, mediates the cAMP-independent localization of multiple T4P structural and regulatory components to the cell poles (PubMed:21527471, PubMed:27297880, PubMed:28583947). This role in directing proteins to the cell pole is not restricted to type IV component and involves other proteins such as the diguanylate cyclase DgcP (By similarity).[UniProtKB:A0A0H2ZC68]<ref>PMID:10846211</ref> <ref>PMID:20345659</ref> <ref>PMID:21097635</ref> <ref>PMID:21527471</ref> <ref>PMID:27297880</ref> <ref>PMID:28583947</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Pseudomonas aeruginosa PAO1]] | ||
[[Category: Burrows | [[Category: Burrows LL]] | ||
[[Category: Daniel-Ivad | [[Category: Daniel-Ivad M]] | ||
[[Category: Howell | [[Category: Howell PL]] | ||
[[Category: Junop | [[Category: Junop MS]] | ||
[[Category: Nguyen | [[Category: Nguyen Y]] | ||
[[Category: Sugiman-Marangos | [[Category: Sugiman-Marangos SN]] | ||
[[Category: Zhang | [[Category: Zhang K]] | ||