Proteopedia

4mal

TPR3 of FimV from P. aeruginosa (PAO1)TPR3 of FimV from P. aeruginosa (PAO1)

Structural highlights

4mal is a 2 chain structure with sequence from Pseudomonas aeruginosa PAO1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.05Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

FIMV_PSEAE Inner membrane hub protein that plays both cAMP-dependent and cAMP-independent roles in twitching motility (PubMed:27297880, PubMed:28583947). Regulates intracellular cyclic AMP (cAMP) levels through the activation of adenylate cyclase CyaB (PubMed:20345659). Plays an essential role in a number of virulence mechanisms including type IV pilus (T4P)-mediated assembly and twitching motility as well as cAMP-dependent virulence gene expression (PubMed:10846211, PubMed:21097635). Mediates also type II secretion (T2S) of lipases and proteases (PubMed:21527471). In addition, mediates the cAMP-independent localization of multiple T4P structural and regulatory components to the cell poles (PubMed:21527471, PubMed:27297880, PubMed:28583947). This role in directing proteins to the cell pole is not restricted to type IV component and involves other proteins such as the diguanylate cyclase DgcP (By similarity).[UniProtKB:A0A0H2ZC68][1] [2] [3] [4] [5] [6]

References

  1. ↑ Semmler AB, Whitchurch CB, Leech AJ, Mattick JS. Identification of a novel gene, fimV, involved in twitching motility in Pseudomonas aeruginosa. Microbiology. 2000 Jun;146 ( Pt 6):1321-32. PMID:10846211
  2. ↑ Fulcher NB, Holliday PM, Klem E, Cann MJ, Wolfgang MC. The Pseudomonas aeruginosa Chp chemosensory system regulates intracellular cAMP levels by modulating adenylate cyclase activity. Mol Microbiol. 2010 May;76(4):889-904. doi: 10.1111/j.1365-2958.2010.07135.x. , Epub 2010 Mar 16. PMID:20345659 doi:http://dx.doi.org/10.1111/j.1365-2958.2010.07135.x
  3. ↑ Wehbi H, Portillo E, Harvey H, Shimkoff AE, Scheurwater EM, Howell PL, Burrows LL. The peptidoglycan-binding protein FimV promotes assembly of the Pseudomonas aeruginosa type IV pilus secretin. J Bacteriol. 2011 Jan;193(2):540-50. doi: 10.1128/JB.01048-10. Epub 2010 Nov 19. PMID:21097635 doi:http://dx.doi.org/10.1128/JB.01048-10
  4. ↑ Michel GPF, Aguzzi A, Ball G, Soscia C, Bleves S, Voulhoux R. Role of fimV in type II secretion system-dependent protein secretion of Pseudomonas aeruginosa on solid medium. Microbiology (Reading). 2011 Jul;157(Pt 7):1945-1954. doi: , 10.1099/mic.0.045849-0. Epub 2011 Apr 28. PMID:21527471 doi:http://dx.doi.org/10.1099/mic.0.045849-0
  5. ↑ Buensuceso RN, Nguyen Y, Zhang K, Daniel-Ivad M, Sugiman-Marangos SN, Fleetwood AD, Zhulin IB, Junop MS, Howell PL, Burrows LL. The Conserved Tetratricopeptide Repeat-Containing C-Terminal Domain of Pseudomonas aeruginosa FimV Is Required for Its Cyclic AMP-Dependent and -Independent Functions. J Bacteriol. 2016 Jul 28;198(16):2263-74. doi: 10.1128/JB.00322-16. Print 2016 , Aug 15. PMID:27297880 doi:http://dx.doi.org/10.1128/JB.00322-16
  6. ↑ Buensuceso RNC, Daniel-Ivad M, Kilmury SLN, Leighton TL, Harvey H, Howell PL, Burrows LL. Cyclic AMP-Independent Control of Twitching Motility in Pseudomonas aeruginosa. J Bacteriol. 2017 Jul 25;199(16):e00188-17. doi: 10.1128/JB.00188-17. Print 2017 , Aug 15. PMID:28583947 doi:http://dx.doi.org/10.1128/JB.00188-17

4mal, resolution 2.05Å

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OCA
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