4hac: Difference between revisions

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-[[Image:4hac.jpg|left|200px]]
-{{STRUCTURE_4hac|  PDB=4hac  |  SCENE=  }}
+==Crystal Structure of the Mevalonate Kinase from an Archaeon Methanosarcina mazei==
+<StructureSection load='4hac' size='340' side='right'caption='[[4hac]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4hac]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanosarcina_mazei_Go1 Methanosarcina mazei Go1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HAC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HAC FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.92&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hac FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hac OCA], [https://pdbe.org/4hac PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hac RCSB], [https://www.ebi.ac.uk/pdbsum/4hac PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hac ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q8PW39_METMA Q8PW39_METMA] Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.[HAMAP-Rule:MF_00217]
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Mevalonate kinase (MVK), which plays an important role in catalysing the biosynthesis of isoprenoid compounds derived from the mevalonate pathway, transforms mevalonate to 5-phosphomevalonate using ATP as a cofactor. Mevalonate kinase from Methanosarcina mazei (MmMVK) was expressed in Escherichia coli, purified and crystallized for structural analysis. Diffraction-quality crystals of MmMVK were obtained by the vapour-diffusion method using 0.32 M MgCl(2), 0.08 M bis-tris pH 5.5, 16%(w/v) PEG 3350. The crystals belonged to space group P2(1)2(1)2, with unit-cell parameters a = 97.11, b = 135.92, c = 46.03 A. Diffraction data were collected to 2.08 A resolution.
-===Crystal Structure of the Mevalonate Kinase from an Archaeon Methanosarcina mazei===
+Crystallization and preliminary X-ray diffraction analysis of mevalonate kinase from Methanosarcina mazei.,Zhuang N, Seo KH, Chen C, Zhou J, Kim SW, Lee KH Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Dec 1;68(Pt 12):1560-3., doi: 10.1107/S1744309112047070. Epub 2012 Nov 28. PMID:23192048<ref>PMID:23192048</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 4hac" style="background-color:#fffaf0;"></div>
-==About this Structure==
+==See Also==
-[[4hac]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanosarcina_mazei_go1 Methanosarcina mazei go1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HAC OCA].
+*[[Mevalonate kinase|Mevalonate kinase]]
-[[Category: Methanosarcina mazei go1]]
+== References ==
-[[Category: Mevalonate kinase]]
+<references/>
-[[Category: Lee, K H.]]
+__TOC__
-[[Category: Zhuang, N.]]
+</StructureSection>
-[[Category: Atp binding]]
+[[Category: Large Structures]]
-[[Category: Ghmp]]
+[[Category: Methanosarcina mazei Go1]]
-[[Category: Phosphorylation]]
+[[Category: Lee KH]]
-[[Category: Transferase]]
+[[Category: Zhuang N]]