Cytochrome b5: Difference between revisions

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<StructureSection load='1b5m' size='350' side='right' caption='Rat heme-containing cytochrome b5 (PDB entry [[1b5m]])' scene='49/490878/Cv/1'>
<StructureSection load='1b5m' size='350' side='right' caption='Rat heme-containing cytochrome b5 (PDB entry [[1b5m]])' scene='49/490878/Cv/1'>


'''Cytochrome b5''' (CB) functions as an electron transport carrier for several membrane-bound oxygenases. <scene name='49/490878/Cv/2'>CB is heme-containing protein</scene>.  The microsomal and mitochondrial CB are membrane-bound while bacterial and other animal tissue CB are soluble.   '''Cytochrome b562''' is the the b-type cytochrome from ''E. coli''.<ref>PMID:12559387</ref>
'''Cytochrome b5''' (CB) functions as an electron transport carrier for several membrane-bound oxygenases<ref>PMID:12481306</ref>. <scene name='49/490878/Cv/2'>CB is heme-containing protein</scene>.  The microsomal and mitochondrial CB are membrane-bound while bacterial and other animal tissue CB are soluble.
</StructureSection>
*'''Cytochrome b558''' is a flavoprotein which is a component of NADPH oxidase<ref>PMID:1324665</ref>
==3D structures of cytochrome b5==
*'''Cytochrome b562''' is the the b-type cytochrome from ''E. coli''.<ref>PMID:12559387</ref>


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
See also [[Hemeproteins]].
{{#tree:id=OrganizedByTopic|openlevels=0|


*Cytochrome b5
==3D structures of cytochrome b5==
[[Cytochrome b5 3D structures]]


**[[1cyo]], [[1ehb]], [[3ozz]] – bCB + heme – bovine<br />
</StructureSection>
**[[1hko]], [[1nx7]] - bCB + heme - NMR<BR />
**[[1es1]], [[1i5u]], [[1lqx]], [[1lr6]], [[1m20]], [[1m2i]], [[1m2m]], [[1m59]], [[1u9m]], [[1u9u]], [[4hin]] - bCB (mutant) + heme<br />
**[[1f03]], [[1f04]], [[1j0q]], [[1sh4]] - bCB (mutant) + heme – NMR<BR />
**[[1b5m]], [[3mus]] – rCB soluble domain + heme – rat<br />
**[[1aqa]], [[1aw3]], [[1axx]], [[2axx]], [[1b5a]], [[1b5b]], [[1blv]], [[1bfx]] - rCB soluble domain + heme – NMR<BR />
**[[1awp]], [[1eue]], [[1icc]], [[1lj0]], [[2i89]] - rCB soluble domain (mutant) + heme<br />
**[[1ib7]], [[1jex]], [[1mny]] - rCB soluble domain (mutant) + heme - NMR<BR />
**[[1iet]], [[1ieu]], [[1i87]], [[1i8c]] – rCB – NMR<BR />
**[[4hil]] – rCB<br />
**[[1do9]], [[2m33]] - CB soluble domain + heme – rabbit – NMR<BR />
**[[1x3x]] - CB + heme – Ascaris suum<br />
**[[2ibj]] - CB + heme – fly<br />
**[[2i96]], [[3ner]] - CB + heme – human - NMR<BR />
**[[3x32]], [[3x33]], [[3x34]], [[3x35]] – pCB N-terminal + heme - pig<br />
 
*Cytochrome b558
 
**[[1cxy]] – CB + heme – ''Ectothiorhodospira shaposhnikovii''
 
*Cytochrome b562


**[[256b]] – EcCB + heme – ''Escherichia coli''<br />
**[[1qpu]] - EcCB + heme – NMR<BR />
**[[1qq3]] - EcCB (mutant) + heme – NMR<BR />
**[[1lm3]], [[2bc5]], [[2qla]], [[3c62]], [[3c63]], [[3de8]], [[3de9]], [[3foo]], [[3fop]], [[3hni]], [[3hnj]], [[3hnk]], [[3hnl]], [[3l1m]], [[3iq5]], [[3iq6]], [[3m79]], [[3nmi]], [[3nmj]], [[3nmk]], [[3m15]], [[3m4b]], [[3m4c]] - EcCB (mutant) + heme<br />
**[[1apc]] – EcCB – NMR<BR />
**[[1m6t]] - EcCB (mutant)
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Latest revision as of 10:27, 11 June 2024


Cytochrome b5 (CB) functions as an electron transport carrier for several membrane-bound oxygenases[1]. . The microsomal and mitochondrial CB are membrane-bound while bacterial and other animal tissue CB are soluble.

  • Cytochrome b558 is a flavoprotein which is a component of NADPH oxidase[2]
  • Cytochrome b562 is the the b-type cytochrome from E. coli.[3]

See also Hemeproteins.

3D structures of cytochrome b5

Cytochrome b5 3D structures


Rat heme-containing cytochrome b5 (PDB entry 1b5m)

Drag the structure with the mouse to rotate

ReferencesReferences

  1. ↑ Porter TD. The roles of cytochrome b5 in cytochrome P450 reactions. J Biochem Mol Toxicol. 2002;16(6):311-6. PMID:12481306 doi:10.1002/jbt.10052
  2. ↑ Sumimoto H, Sakamoto N, Nozaki M, Sakaki Y, Takeshige K, Minakami S. Cytochrome b558, a component of the phagocyte NADPH oxidase, is a flavoprotein. Biochem Biophys Res Commun. 1992 Aug 14;186(3):1368-75. PMID:1324665 doi:10.1016/s0006-291x(05)81557-8
  3. ↑ Schenkman JB, Jansson I. The many roles of cytochrome b5. Pharmacol Ther. 2003 Feb;97(2):139-52. PMID:12559387

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