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==Crystal structure of beta-parvin CH2 domain in complex with paxillin LD1 motif== | ==Crystal structure of beta-parvin CH2 domain in complex with paxillin LD1 motif== | ||
<StructureSection load='4edn' size='340' side='right' caption='[[4edn]], [[Resolution|resolution]] 2.90Å' scene=''> | <StructureSection load='4edn' size='340' side='right'caption='[[4edn]], [[Resolution|resolution]] 2.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4edn]] is a 17 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4edn]] is a 17 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EDN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EDN FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4edn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4edn OCA], [https://pdbe.org/4edn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4edn RCSB], [https://www.ebi.ac.uk/pdbsum/4edn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4edn ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/PARVB_HUMAN PARVB_HUMAN] Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration.<ref>PMID:11402068</ref> <ref>PMID:15005707</ref> <ref>PMID:15284246</ref> <ref>PMID:15159419</ref> <ref>PMID:18325335</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 4edn" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Parvin 3D structures|Parvin 3D structures]] | |||
*[[Paxillin|Paxillin]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
| Line 24: | Line 28: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Boggon | [[Category: Large Structures]] | ||
[[Category: Calderwood | [[Category: Boggon TJ]] | ||
[[Category: Chayen | [[Category: Calderwood DA]] | ||
[[Category: Draheim | [[Category: Chayen NE]] | ||
[[Category: Li | [[Category: Draheim KM]] | ||
[[Category: Stiegler | [[Category: Li X]] | ||
[[Category: Stiegler AL]] | |||