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| {{STRUCTURE_1fe3| PDB=1fe3 | SIZE=400| SCENE= |right|CAPTION=Human brain-type fatty acid-binding protein complex with oleate, [[1fe3]] }}
| | <StructureSection load='1fe3' size='350' side='right' scene='48/487562/Cv/4' caption='Human brain-type fatty acid-binding protein complex with oleate (PDB code [[1fe3]]) '> |
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| | '''Fatty acid-binding protein''' (FABP) are carrier proteins for fatty acids and other lipophilic substances. They facilitate the transfer of fatty acids between extra- and intracellular membranes. FABS coordinate lipid trafficking and signaling in cells<ref>PMID:16424607</ref>. Various FABS differ in their tissue expression. |
| Please use the "3D" button above this box to insert a Jmol applet (molecule) on this page.
| | *'''IFABP''' is intestinal; |
| Or use the four-green-boxes-button to insert scrollable text adjacent
| | *'''HFABP''' is heart-type; |
| to a Jmol applet. Check out the other buttons as well!
| | *'''BFABP''' is brain-type; |
| -->
| | *'''LFABP''' is liver-type; |
| '''Fatty acid-binding protein''' (FABP) are carrier proteins for fatty acids and other lipophilic substances. They facilitate the transfer of fatty acids between extra- and intracellular membranes. FABS coordinate lipid trafficking and signaling in cells. Some FABSs are linked to metabolic and inflammatory pathways. Various FABS differ in their tissue expression. IFABP is intestinal; HFABP is heart-type; BFABP is brain-type; LFABP is liver-type; AFABP is adipocyte; LMDABP is from flight muscle; TFABP is from testis; EXFABP is extracellular. | | *'''AFABP''' is adipocyte; |
| | *'''LMDABP''' is from flight muscle; |
| | *'''TFABP''' is from testis. |
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| ==3D structures of fatty acid-binding protein== | | == Relevance == |
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | Some FABSs are linked to metabolic and inflammatory pathways. |
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| '''Intestinal fatty acid-binding protein'''
| | == Structural insights == |
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| [[1ael]], [[1a57]], [[1sa8]] - rIFABP – rat – NMR<BR />
| | The <scene name='48/487562/Cv/5'>FABP active site binds fatty acids</scene> ({{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar}})<ref>PMID:10854433</ref>. |
| [[1t8v]] - rIFABP (mutant) – NMR<BR />
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| [[1ifb]], [[1ifc]] - rIFABP <br />
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| [[1dc9]] - rIFABP (mutant)<br />
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| [[1kzw]], [[3ifb]] - hIFABP – human – NMR<BR />
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| [[1kzx]] - hIFABP (mutant) – NMR<BR />
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| ''Intestinal fatty acid-binding protein binary complex''
| | ==3D structures of fatty acid-binding protein== |
| | | [[Fatty acid-binding protein 3D structures]] |
| [[3akm ]] - hIFABP + fatty acid analog<br /> | |
| [[3akn]], [[1icm]], [[1icn]], [[2ifb]] - rIFABP + fatty acid analog<br />
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| [[1ure]] - rIFABP + palmitate – NMR<BR />
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| '''Epidermal fatty acid-binding protein'''
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| [[1b56]], [[1jjj]] - hEFABP <br />
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| [[4azr]] - hEFABP + fatty acid<br />
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| [[4azn]], [[4azo]] - mEFABP <br />
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| [[4azp]], [[4azq]] - mEFABP + fatty acid<br />
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| [[4azm]] - hEFABP + inhibitor<br />
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| '''Heart-type fatty acid-binding protein'''
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| [[1g5w]] - hHFABP – NMR<BR />
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| [[3rsw]] – hHFABP<br />
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| [[3wbg]] – hHFABP + sulfonate derivative<br />
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| [[1bwy]] – HFABP – bovine<br />
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| '''Brain-type fatty acid-binding protein'''
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| [[1fdq]], [[1jjx]] - hBFABP<br />
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| [[1fe3]] - hBFABP + oleate<br />
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| '''Liver-type fatty acid-binding protein'''
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| [[1p6p]] - LFABP – toad<br />
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| [[1tvq]], [[1mvg]] - cLFABP – chicken<br />
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| [[1zry]] - cLFABP - NMR<BR />
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| [[2f73]], [[3stn]], [[3b2h]], [[3b2i]], [[3b2j]], [[3b2k]], [[3b2l]], [[3vg2]], [[3vg3]], [[3vg4]], [[3vg5]], [[3vg6]], [[3vg7]] - hLFABP<br />
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| [[2py1]], [[2l67]], [[2l68]] - hLFABP – NMR<BR />
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| [[2ju3]], [[2ju7]] - rLFABP – NMR<BR />
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| [[2ft9]] – AmLFABP - ''Ambystoma mexicanum''
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| ''Liver-type fatty acid-binding protein binary complex''
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| [[3stk]], [[3stm]] - hLFABP + palmitate<br />
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| [[2lkk]] - hLFABP + oleate – NMR<br />
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| [[2ju8]] - rLFABP + oleate – NMR<BR />
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| [[1lfo]] - rLFABP + oleate<br />
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| [[1tw4]], [[2jn3]], [[2lfo]] - cLFABP + cholate<br />
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| [[2jn3]] - cLFABP + chenodeoxycholate<br />
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| [[2k62]] - cLFABP + bile acid-based Gd chelate<br />
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| [[2ftb]] - AmLFABP + oleate<br />
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| [[2qo4]] – zLFABP + cholate – zebrafish<br />
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| [[2qo5]], [[2qo6]] – zLFABP (mutant) + cholate <br />
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| '''Adipocyte fatty acid-binding protein'''
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| [[1tou]], [[2hnx]], [[3q6l]], [[3rzy]] - hAFABP<br />
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| [[1lib]], [[1alb]] – mAFABP<br />
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| [[1g7n]], [[1ab0]], [[1acd]] - mAFABP (mutant) <br />
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| [[1tow]] - hAFABP + carbazole butanoic acid<br />
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| [[2nnq]], [[3fr2]], [[3fr4]], [[3fr5]] - hAFABP + inhibitor<br />
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| [[3p6c]] - hAFABP + citrate<br />
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| [[3p6d]], [[3p6e]] - hAFABP + propionate derivative<br />
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| [[3p6f]] - hAFABP + phenyl-butyrate<br />
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| [[3p6g]], [[3p6h]] - hAFABP + ibuprofen<br />
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| [[2qm9]] - mAFABP + troglitazone <br />
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| [[2q9s]], [[1lid]], [[1lie]], [[1lif]], [[1adl]] - mAFABP + fatty acid<br />
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| [[1g74]] - mAFABP (mutant) + fatty acid <br />
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| [[3hk1]], [[3js1]], [[3jsq]] - mAFABP + inhibitor<br />
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| [[1lic]], [[2ans]] – mAFABP + sulfonic acid derivative<br />
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| [[1a18]] - mAFABP + phenanthroline <br />
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| [[1a2d]] - mAFABP + pyridoxamine <br />
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| '''Flight muscle fatty acid-binding protein'''
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| [[2flj]], [[1ftp]] - LMFABP – locust
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| '''Muscle fatty acid-binding protein'''
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| [[2hmb]] – hMFABP <br />
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| [[1hmr]], [[1hms]], [[1hmt]] – hMFABP + fatty acid<br />
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| '''Testis fatty acid-binding protein'''
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| [[4a60]] - hTFABP
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| '''Extracellular fatty acid-binding protein'''
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| [[2kt4]] - qEXFABP – quail<br />
| | </StructureSection> |
| [[2lbv]] - qEXFABS + enterobactin<br />
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| [[3sao]] - cEXFABP + myristoyl lysophosphatidic acid
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| [[2poa]] - SmFABP (mutant) - ''Schistosoma mansoni'' – NMR<BR />
| | == References == |
| [[1mdc]] – FABP – tobacco hornworm<br />
| | <references/> |
| [[4jgx]] - FABP – ''Yarrowia lipolytica''<br />
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| [[1vyf]], [[1vyg]] – SmFABP + fatty acid<br />
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| [[3w9k]] – FABP + fatty acid – ''Sulfolobus tokodaii''<br />
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| [[Category:Topic Page]] | | [[Category:Topic Page]] |