Histone methyltransferase: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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+<StructureSection load='' size='350' side='right' caption='Human histone-lysine N-methyltrasferase (magenta) complex with methylated lysine histone H3 peptide (green) and S-adenosyl homocysteine (SAH) (PDB entry [[1o9s]])' scene='46/467278/Cv/1'>
+== Function ==
+'''Histone methyltransferase''' (HMT) are '''histone-lysine N-methyltransferase''' (KHMT)  and '''histone-arginine N-methyltransferase''' (RHMT)  which catalyzes the transfer of methyl groups to lysine and arginine residues of histones<ref>PMID:15248813</ref>.  HMT use S-adenosyl methionine (SAM) or S-adenosyl homocysteine (SAH) as the methyl donor.  KHMT can be SET domain-containing or non-SET domain-containing.  The SET domain contains the catalytic core of KHMT and targets the lysine tail region of KHMT.  CxxC domain is a zinc finger domain.
+For SET7/9 see [[Histone Lysine Methyltransferase SET7/9]].
-'''Histone methyltransferase''' (HMT) are histone-lysine N-methyltransferase (KHMT)  and histone-arginine N-methyltransferase (RHMT)  which catalyzes the transfer of methyl groups to lysine and arginine residues of histones.  HMT use S-adenosyl methionine (SAM) or S-adenosyl homocysteine (SAH) as the methyl donor.
+*'''euchromatin histone methyltransferase''' dimethylates histone H3 at Lys 9 resulting in transcriptional repression<ref>PMID:32684241</ref>.
+*'''DOT1L histone methyltransferase''' methylates histone H3 at Lys 79 resulting in transcriptional repression<ref>PMID:35495127</ref>.
-[[1nw3]] – hHMT DOT1L – human
+== Relevance ==
+Inhibitors of the histone-lysine N-methyltransferase SMYD2 which represses the tumor-suppressing activities of p53 are studied as cancer therapy drugs<ref>PMID:21782458</ref>.
-[[2igq]] – hHMT-1 C terminal
+== Disease ==
+Aberrant HMT plays a role in cancer, intellectual disability syndromes and regulation of tissue aging<ref>PMID:22473383</ref>.
-===Histone-lysine N-methyltransferase===
+== Structural highlights ==
+Human <scene name='46/467278/Cv/6'>KHMT binds SAH in the peptide binding groove with the histone H3 peptide assuming an extended conformation and the methylated lysine</scene> inserted in a hydrophobic environment<ref>PMID:12540855</ref>. Water molecules shown as red spheres
-[[2j8a]] – KHMT SET1 RRM domain – yeast
+== 3D Structures of histone methyltransferase ==
+[[Histone methyltransferase 3D structures]]
-[[3s8s]] – hKHMT SETD1A RRM domain
+</StructureSection>
-[[3rib]] – hKHMT Smyd2 + SAH
+== References ==
+<references/>
-[[3s7b]] - hKHMT Smyd2 + SAM + inhibitor
+[[Category:Topic Page]]
-[[3s7d]], [[3s7f]], [[3tg5]] - hKHMT Smyd2 + SAH + p53 peptide
-[[3s7j]], [[3tg4]] - hKHMT Smyd2 + SAM