Thrombospondin: Difference between revisions
Jump to navigation
Jump to search
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| (12 intermediate revisions by 3 users not shown) | |||
| Line 1: | Line 1: | ||
<StructureSection load=' | <StructureSection load='' size='350' side='right' caption='Human TSP-1 Nterminal complex with Arixtra heparin (PDB code [[1za4]])' scene='74/748873/Cv/3'> | ||
== Function == | == Function == | ||
Thrombospondin (TSP) are glycoproteins released in response to thrombin stimulation. TSP is a transient component of extracellular matrix in developing tissues<ref>PMID:9304800</ref>. | '''Thrombospondin''' (TSP) are glycoproteins released in response to thrombin stimulation. TSP is a transient component of extracellular matrix in developing tissues<ref>PMID:9304800</ref>. | ||
== Relevance == | == Relevance == | ||
TSP-1 and TSP-2 are potent inhibitors of angiogenesis and thus are studied in cancer treatments<ref>PMID:22553494</ref>. | TSP-1 and TSP-2 are potent inhibitors of angiogenesis and thus are studied in cancer treatments<ref>PMID:22553494</ref>. | ||
== Disease == | |||
TSP-2 mutation is associated with coronary artery disease<ref>PMID:18499674</ref>. | |||
== Structural highlights == | == Structural highlights == | ||
The N-terminal of TSP-1 mediates its interaction with integrins during cell adhesion, with lipoproteinreceptor-related protein during uptake and clearance and with fibrinogen during platelet aggregation. The <scene name='74/748873/Cv/4'>arginine and lysine side chains of the N-terminal interact with the heparin sulfate groups</scene><ref>PMID:16407063</ref>. | |||
</StructureSection> | </StructureSection> | ||
| Line 14: | Line 18: | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
{{#tree:id=OrganizedByTopic|openlevels=0| | |||
*Thrombospondin-1 | |||
**[[1ux6]] – hTSP-1 C-terminal (mutant) 831-1170 + Ca - human<br /> | |||
**[[1lsl]], [[3r6b]] – hTSP-1 repeats 2-3 434-547<br /> | |||
**[[1z78]], [[2erf]], [[2es3]], [[2ouh]], [[2ouj]] – hTSP-1 N-terminal 25-233<br /> | |||
**[[7yyk]] – hTSP-1 378-547<br /> | |||
**[[1za4]] – hTSP-1 N-terminal + heparin<br /> | |||
*Thrombospondin-2 | |||
**[[1yo8]] – hTSP-2 C-terminal<br /> | |||
**[[2rhp]] – hTSP-2 signature domain (mutant)<br /> | |||
}} | |||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | |||