Mannan-binding lectin serine protease: Difference between revisions
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<StructureSection load=' | <StructureSection load='' size='340' side='right' caption='Human MASP-2 chain A sushi 2 domain (grey) and chain B catalytic domain (green) complex with protease inhibitor SGPI-2 (wheat) and sulfate (PDB code [[3tvj]])' scene='74/748867/Cv/1'> | ||
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== Structural highlights == | == Structural highlights == | ||
<scene name='74/748867/Cv/2'>Human MASP-2 sushi 2 domain and catalytic domain complex with protease inhibitor SGPI-2</scene>. MASP-1, MASP-2 and MASP-3 are 680, 671 and 709 amino acid long respectively. They show a similar domain structure with A chain containing domains CUB1, EGF, CUB2, CCP1, CCP2 followed by a short link region and B chain which is the catalytic domain. The catalytic domain contains the classic serine protease active triad of serine, histidine and aspartic acid<ref>PMID:12396007</ref>, <ref>PMID:22511776</ref>. | <scene name='74/748867/Cv/2'>Human MASP-2 sushi 2 domain and catalytic domain complex with protease inhibitor SGPI-2</scene>.''' MASP-1, MASP-2 and MASP-3''' are 680, 671 and 709 amino acid long respectively. They show a similar domain structure with A chain containing domains CUB1, EGF, CUB2, CCP1, CCP2 followed by a short link region and B chain which is the catalytic domain. The catalytic domain contains the classic serine protease active triad of serine, histidine and aspartic acid<ref>PMID:12396007</ref>, <ref>PMID:22511776</ref>. | ||
</StructureSection> | </StructureSection> | ||
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
*Mannan- | *Mannan-binding serine protease 1 | ||
**[[4aqb]] – hMASP-1 - human<br /> | **[[4aqb]] – hMASP-1 - human<br /> | ||
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**[[3pob]] – rMASP-1 CUB2 domain + MBL collagen-like peptide - rat <br /> | **[[3pob]] – rMASP-1 CUB2 domain + MBL collagen-like peptide - rat <br /> | ||
**[[3poe]], [[3pof]], [[3pog]], [[3poi]], [[3poj]] – rMASP-1 CUB2 domain <br /> | **[[3poe]], [[3pof]], [[3pog]], [[3poi]], [[3poj]] – rMASP-1 CUB2 domain <br /> | ||
**[[ | **[[5ckq]] – rMASP-1 CUB1-EGF-CUB2 domain <br /> | ||
*Mannan- | *Mannan-binding serine protease 2 | ||
**[[5jpm | **[[5jpm]] – hMASP-2 (mutant) + complement C4-A <br /> | ||
**[[3tvj]] – hMASP-2 chain A sushi 2 domain, chain B catalytic domain + SGPI-2 <br /> | **[[3tvj]] – hMASP-2 chain A sushi 2 domain, chain B catalytic domain + SGPI-2 <br /> | ||
**[[1q3x]] – hMASP-2 catalytic domain <br /> | **[[1q3x]] – hMASP-2 catalytic domain <br /> | ||
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**[[1nt0]], [[5cis]], [[5ckm]], [[5ckn]] – hMASP-2 CUB1-EGF-CUB2 domain <br /> | **[[1nt0]], [[5cis]], [[5ckm]], [[5ckn]] – hMASP-2 CUB1-EGF-CUB2 domain <br /> | ||
*Mannan- | *Mannan-binding serine protease 3 | ||
**[[4kkd]] – hMASP-3 (mutant)<br /> | **[[4kkd]] – hMASP-3 (mutant)<br /> | ||