Mannan-binding lectin serine protease: Difference between revisions
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<StructureSection load=' | <StructureSection load='' size='340' side='right' caption='Human MASP-2 chain A sushi 2 domain (grey) and chain B catalytic domain (green) complex with protease inhibitor SGPI-2 (wheat) and sulfate (PDB code [[3tvj]])' scene='74/748867/Cv/1'> | ||
== Function == | == Function == | ||
'''Mannan-binding lectin serine protease''' (MASP) are proteases associated with mannan-binding lectin (MLB). The lectin pathway of complement is part of the innate immunity. The pathway activation occurs via recognition of pathogens by MBL followed by activation of MASP leading to activation of the complement system<ref>PMID:22670777</ref>. | '''Mannan-binding lectin serine protease''' (MASP) are proteases associated with mannan-binding lectin (MLB). The lectin pathway of complement is part of the innate immunity. The pathway activation occurs via recognition of pathogens by MBL followed by activation of MASP leading to activation of the complement system<ref>PMID:22670777</ref>. | ||
== Relevance == | == Relevance == | ||
MASP-1 and MASP-2 contribute to clot formation and may represent an important link between inflammation and thrombosis. MASP levels may be altered in vascular diseases<ref>PMID:23607747</ref>. | |||
== Structural highlights == | == Structural highlights == | ||
<scene name='74/748867/Cv/2'>Human MASP-2 sushi 2 domain and catalytic domain complex with protease inhibitor SGPI-2</scene>.''' MASP-1, MASP-2 and MASP-3''' are 680, 671 and 709 amino acid long respectively. They show a similar domain structure with A chain containing domains CUB1, EGF, CUB2, CCP1, CCP2 followed by a short link region and B chain which is the catalytic domain. The catalytic domain contains the classic serine protease active triad of serine, histidine and aspartic acid<ref>PMID:12396007</ref>, <ref>PMID:22511776</ref>. | |||
</StructureSection> | </StructureSection> | ||
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
*Mannan- | *Mannan-binding serine protease 1 | ||
**[[4aqb]] – hMASP-1 - human<br /> | **[[4aqb]] – hMASP-1 - human<br /> | ||
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**[[3pob]] – rMASP-1 CUB2 domain + MBL collagen-like peptide - rat <br /> | **[[3pob]] – rMASP-1 CUB2 domain + MBL collagen-like peptide - rat <br /> | ||
**[[3poe]], [[3pof]], [[3pog]], [[3poi]], [[3poj]] – rMASP-1 CUB2 domain <br /> | **[[3poe]], [[3pof]], [[3pog]], [[3poi]], [[3poj]] – rMASP-1 CUB2 domain <br /> | ||
**[[5ckq]] – rMASP-1 CUB1-EGF-CUB2 domain <br /> | |||
*Mannan- | *Mannan-binding serine protease 2 | ||
**[[5jpm | **[[5jpm]] – hMASP-2 (mutant) + complement C4-A <br /> | ||
**[[3tvj]] – hMASP-2 chain A sushi 2 domain, chain B catalytic domain + SGPI-2 <br /> | **[[3tvj]] – hMASP-2 chain A sushi 2 domain, chain B catalytic domain + SGPI-2 <br /> | ||
**[[1q3x]] – hMASP-2 catalytic domain <br /> | **[[1q3x]] – hMASP-2 catalytic domain <br /> | ||
**[[1zjk]] – hMASP-2 catalytic domain (mutant) <br /> | **[[1zjk]] – hMASP-2 catalytic domain (mutant) <br /> | ||
**[[1nt0]] – hMASP-2 CUB1-EGF-CUB2 domain <br /> | **[[1nt0]], [[5cis]], [[5ckm]], [[5ckn]] – hMASP-2 CUB1-EGF-CUB2 domain <br /> | ||
*Mannan- | *Mannan-binding serine protease 3 | ||
**[[4kkd]] – hMASP-3 (mutant)<br /> | **[[4kkd]] – hMASP-3 (mutant)<br /> | ||
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== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | |||