2hxr: Difference between revisions
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==Structure of the ligand binding domain of E. coli CynR, a transcriptional regulator controlling cyanate metabolism== | |||
<StructureSection load='2hxr' size='340' side='right'caption='[[2hxr]], [[Resolution|resolution]] 2.05Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2hxr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HXR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HXR FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hxr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hxr OCA], [https://pdbe.org/2hxr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hxr RCSB], [https://www.ebi.ac.uk/pdbsum/2hxr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hxr ProSAT], [https://www.topsan.org/Proteins/MCSG/2hxr TOPSAN]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/CYNR_ECOLI CYNR_ECOLI] Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR-cynTSX intergenic region. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hx/2hxr_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hxr ConSurf]. | |||
<div style="clear:both"></div> | |||
== | ==See Also== | ||
*[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[ | [[Category: Escherichia coli K-12]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Cuff | [[Category: Cuff ME]] | ||
[[Category: Edwards | [[Category: Edwards AM]] | ||
[[Category: Evdokimova | [[Category: Evdokimova E]] | ||
[[Category: Joachimiak | [[Category: Joachimiak A]] | ||
[[Category: Kagan | [[Category: Kagan O]] | ||
[[Category: Savchenko A]] | |||
[[Category: Savchenko | [[Category: Singer AU]] | ||
[[Category: Singer | |||
Latest revision as of 11:10, 30 October 2024
Structure of the ligand binding domain of E. coli CynR, a transcriptional regulator controlling cyanate metabolismStructure of the ligand binding domain of E. coli CynR, a transcriptional regulator controlling cyanate metabolism
Structural highlights
FunctionCYNR_ECOLI Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR-cynTSX intergenic region. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also |
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